Abstract
RECENT work in several laboratories indicates that 2-hydroxylated œstrogens may be important metabolites of these naturally occurring steroid hormones. Thus King1,2 has shown that œstriol is converted into 2-hydroxyœstriol and 2-methoxyœstriol by incubation with rat liver preparations in the presence of molecular oxygen. Work on the oxidation of di- and triphosphopyridine nucleotides by phenolases with oxygen, induced by natural and synthetic phenolicœstrogens3, clearly demonstrates that o-diphenols are involved in this system. Mueller4 has claimed that formate incorporation into uterine tissue is increased by the addition of o-hydroxylated derivatives of œstradiol in vitro. Finally, 2-methoxyœstrone5,6 and 2-methoxyœstriol7 have been isolated from human urine. It is therefore of importance to devise practical syntheses of the 2-hydroxyœstrogens, in order to facilitate further biochemical and biological investigations.
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References
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COOMBS, M. 2-Hydroxyœstrogens. Nature 188, 317–318 (1960). https://doi.org/10.1038/188317a0
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DOI: https://doi.org/10.1038/188317a0
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