Abstract
THE human adult hæmoglobins and canine hæmoglobin recombine asymmetrically, that is: 
after both short and prolonged exposure to dilute acid1–5. At pH. 11, hæmoglobin A dissociates into half-molecules6; furthermore, re-association of a mixture of labelled hæmoglobin S and hæmoglobin A after 24 hr. at pH. 11 results in the exchange of the β2 sub-units7. We now wish to report a series of experiments which indicate that hæmoglobin also recombines asymmetrically after short exposure to alkali.
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ROBINSON, E., ITANO, H. Asymmetrical Recombination of Alkali-dissociated Hæmoglobin Mixtures. Nature 185, 547–549 (1960). https://doi.org/10.1038/185547b0
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DOI: https://doi.org/10.1038/185547b0
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