Abstract
THE induction of bone tumours by radium and other ‘bone-seeking’ radioactive materials is now well known. It was originally observed in human cases of radium poisoning1–4. Experimentally, similar tumours have been produced in a wide range of animal species following the administration of either radium5–9 or a variety of ‘bone-seeking’ radioactive isotopes such as strontium-89, strontium-90, plutonium-239 and calcium-4510–19. Tumours occur in the neighbourhood of sites of maximum isotope deposition and retention (see ref. 13). In young rabbits receiving a single injection of strontium-9013, tumours occurred most frequently in the metaphysial regions of the long bones, while in both old and young rabbits20 they occurred adjacent to growing teeth in the mandible and maxilla.
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SISSONS, H., VAUGHAN, J. Ear Tumours in Rabbits receiving Strontium-90. Nature 185, 399–401 (1960). https://doi.org/10.1038/185399a0
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DOI: https://doi.org/10.1038/185399a0
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