Abstract
IN the course of a study of immunological responsiveness of chickens to foreign red blood cells our interest was attracted by the observed discrepancy between high agglutination titres of immune chicken sera and their inability to show lytic properties in the presence of complement. It is well known that different antibody–antigen systems exhibit different abilities to fix guinea pig complement when mammals are used as antibody producers1. The failure of immune bird sera to show a significant complement-fixing activity was mentioned by Meyer2 and by Rice3 in birds infected with ornithosis virus and S. pullorum. It was postulated that avian antibody formed with antigen non-complement-fixing aggregates4, and that avian antibody lacked some character that was important for combining with complement5. This problem, however, was not further explored, and all available data were based on the experiments made with guinea pig complement. It seemed, therefore, reasonable to investigate in a preliminary way whether or not chicken antibody hæmolyses red cells in the presence of complement from different animal species.
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References
Kabat, E. A., and Mayer, M. M., “Experimental Immunochemistry”, 130 (Charles C. Thomas Pub., Springfield, 1948).
Meyer, K. F., in “Diseases of Poultry”, 455 (Iowa State College Press, Arwes, 1944).
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Meyer, K. F., and Eddie, B., in “Diagnostic Procedures for Virus and Rickettsial Diseases”, 399 (Pub. Office, Amer. Public Health Assoc., New York City, 1956).
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JANKOVIĆ, B., ISAKOVIĆ, K. Hæmolytic Properties of Immune Chicken Antibody. Nature 185, 322–323 (1960). https://doi.org/10.1038/185322b0
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DOI: https://doi.org/10.1038/185322b0
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