Abstract
IF it is assumed that irradiation of a tumour results in immediate or eventual sterilization of a given proportion of its constituent cells1, that the magnitude of this effect is an exponential function of dosage2,3, and that the ability of the residual viable cells to grow progressively depends upon whether their number exceeds that critical value below which their growth is effectively suppressed by host-resistance factors alone4,5, then the radiosensitivity, or mean lethal dose, of the individual cells, and the critical cell number for the C3H adenocarcinoma growing under various conditions, can be estimated indirectly from observed data on the radiosensitivity of the tumour in vivo.
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References
Scott, O. C. A., “Advances in Biological and Medical Physics”, 6, 121 (Academic Press, New York, 1958).
Puck, T. T., and Marcus, P. I., J. Exp. Med., 103, 653 (1956).
Hewitt, H. B., and Wilson, C. W., Nature, 183, 1060 (1959). Brit. J. Cancer, 13, 69 (1959).
Revesz, L., J. Nat. Cancer Inst., 20, 1157 (1958).
Klein, G., Cancer Res., 19, 343 (1959).
Cohen, A., and Cohen, L., Brit. J. Cancer, 7, 231, 452 (1953); 8, 303, 313, 522 (1954); 9, 600 (1955); 10, 312 (1956); 11, 563 (1957); 12, 561 (1958).
Cohen, L., and Cohen, A., Brit. J. Radiol., 33, 18 (1959).
Cohen, L., and Cohen, A., Nature, 183, 692 (1959).
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COHEN, A., COHEN, L. Estimation of the Cellular Lethal Dose and the Critical Cell Number for the C3HMouse Mammary Carcinoma from Radiosensitivity Studies in vivo . Nature 185, 262–263 (1960). https://doi.org/10.1038/185262a0
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DOI: https://doi.org/10.1038/185262a0
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