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Effect of Cytotoxic Agents on Antibody Production

Abstract

IT has long been known that antibody-production may be inhibited by certain cytotoxic agents, for example, X-radiation, benzene and mustard gas1. More recently, the number of agents reported to have this effect has been extended to include cortisone2, nitrogen mustards3, colchicine4, deoxypyridoxine5, 8-azaguanine6, various carcinogens7, β-3-thienylalanine8, 6-mercaptopurine9 and amethopterin10. Many of these are potent anti-tumour compounds.

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References

  1. Hektoen, L., J. Infect. Dis., 17, 415 (1915): 19, 69 (1916). Hektoen, L., and Corper, H. J., ibid., 28, 279 (1921).

    Article  CAS  Google Scholar 

  2. Kass, E. H., and Finland, M., “Ann. Rev. Microbiol.”, 7, 361 (1953).

    Article  CAS  Google Scholar 

  3. Spurr, C. L., Proc. Soc. Exp. Biol., 64, 259 (1947). Phillips, F. S., Hopkins, F. H., and Freeman, M. L. H., J. Immunol., 55, 289 (1947).

    Article  CAS  Google Scholar 

  4. Forman, C., Seifter, J., and Ehrich, W. E., J. Allergy, 20, 273 (1949) Fagraeus, A., and Gormsen, H., Acta Path. Micro. Scand., 33, 421 (1953).

    Article  CAS  Google Scholar 

  5. Stoerck, H. C., Ann. N.Y. Acad. Sci., 52, 1302 (1950).

    Article  ADS  Google Scholar 

  6. Malmgren, R. A., Bennison, B. E., and McKinley, T. W., J. Nat. Cancer Inst., 12, 807 (1952).

    CAS  PubMed  Google Scholar 

  7. Malmgren, R. A., Bennison, B. E., and McKinley, T. W., Proc. Soc. Exp. Biol. Med., 79, 484 (1952).

    Article  CAS  Google Scholar 

  8. Wissler, R. W., Frazier, L. F., Soules, K. H., Barker, P., and Bristow, E. C., Arch. Path., 62, 62 (1956).

    CAS  Google Scholar 

  9. Schwartz, R., Stack, J., and Damashek, W., Proc. Soc. Exp. Biol. Med., 99, 164 (1958).

    Article  CAS  Google Scholar 

  10. Uphoff, D., Proc. Soc. Exp. Biol. Med., 99, 651 (1958).

    Article  CAS  Google Scholar 

  11. Fagraeus, A., Acta Path. Micro. Scand., Supp. 93, 20 (1952). Berglund, K., ibid., 38, 311 (1956). Taliaferro, W. M., Ann. N.Y. Acad. Sci., 69, 745 (1957).

    Google Scholar 

  12. Shamaeva, E. M., and Pankova, S. S., J. Microbiol. Epidemiol. Immunobiol., 28, 489 (1957). Green, D. M., Brit. J. Exp. Path., 39, 192 (1958)

    CAS  Google Scholar 

  13. Burnet, F. M., “Enzyme, Antigen and Virus” (Cambridge, 1956). Schweet, R. S., and Owen, R. D., J. Cell Comp. Physiol., 50, Supp. 1, 199 (1957). Schultz, J., Science, 129, 937 (1959).

    Google Scholar 

  14. Ledoux, L., and Baltus, E., Exper., 10, 500 (1954). Ledoux, L., Nature, 176, 36 (1955).

    CAS  Google Scholar 

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BERENBAUM, M. Effect of Cytotoxic Agents on Antibody Production. Nature 185, 167–168 (1960). https://doi.org/10.1038/185167a0

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