Abstract
LYMPHOID tissue exposed to certain lipid emulsions undergoes a gross and widespread necrosis, while exposure either to the lipid or emulsifier alone produces only minor ‘reactive’ changes. This phenomenon, which, so far as we know, had not been previously reported, was first described by one Bennett and Shivas1. Further work still in progress has shown that necrosis can be produced by a wide variety of lipid emulsions and the effect appears to be a general property of these. Emulsions containing 20 per cent w/v ethyl stearate, ethyl laurate, ‘F 99’ (a preparation of ethyl esters of linoleic and linolenic acids), stearic acid, lauric acid, olive oil and liquid paraffin have been given in a single dose of 2 ml. to fully grown young rats by the intraperitoneal route under direct vision at laparotomy with ether anæsthesia. The emulsifiers used are ‘Tween 80’, ox bile and gum acacia. Glyceryl monostearate emulsions were prepared without any added emulsifying agent. Unemulsified lipids and aqueous solutions of emulsifying agents (with the exception of ox bile) have also been administered separately at concentrations equivalent to those in the emulsions.
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Bennett, H. S., and Shivas, A. A., J. Fac. Radiol., 5, 261 (1954).
Gillman, J., and Gillman, T., Clin. Proc., 8, 222 (1949).
Meyer, C. E., Fancher, J. A., Schurr, P. E., and Webster, H. D., Metabolism, 6, 591 (1957).
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SHIVAS, A., FRASER, G. Lymphoid Necrosis Induced by Lipid Emulsions. Nature 184, 1813 (1959). https://doi.org/10.1038/1841813a0
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DOI: https://doi.org/10.1038/1841813a0
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