Abstract
Nossal and Lederberg1 described an ingenious and elegant method for showing that single cells from ratlymph nodes, simultaneously stimulated with two antigens, formed antibody to one or other antigen but never to both.
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References
Nossal, G. J. V., and Lederberg, J., Nature, 181, 1419 (1958).
Coons, A. H., and Kaplan, M. H., J. Exp. Med., 91, 1 (1950).
Coons, A. H., Leduc, E. H., and Connolly, J. M., J. Exp. Med. 102, 49 (1955).
Chadwick, C. S., McEntegart, M. G., and Nairn, R. C., Lancet, i, 412 (1958).
Rich, A. R., Lewis, M. R., and Wintrobe, M. M., Bull. J. Hop. Hosp. 65, 311 (1939).
Burnet, F. M., Aust. J. Sci., 20, 67 (1957).
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White, R. G., Coons, A. H., and Connolly, J. M., J. Exp. Med., 102, 73 (1955).
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WHITE, R. Antibody Production by Single Cells. Nature 182, 1383–1384 (1958). https://doi.org/10.1038/1821383a0
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DOI: https://doi.org/10.1038/1821383a0
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