Abstract
IT has been observed that upon attempted distillation of the oxime of 2-phenylcyclohept-2-enone in a high vacuum, thermal cyclization takes place with the formation of cycloheptenoindole1. If the generality of this reaction could be demonstrated, a valuable new route would be available towards obtaining certain natural products containing the indole nucleus, employing starting materials more readily available than those containing a preformed indole system. We wish to report the extension of the thermal cyclization reaction of oximes to a number of new cases.
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Ginsburg, D., and Pappo, R., J. Amer. Chem. Soc., 75, 1094 (1953).
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LÖFFLER, A., GINSBURG, D. A New Synthesis of Carbazoles. Nature 172, 820 (1953). https://doi.org/10.1038/172820b0
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DOI: https://doi.org/10.1038/172820b0
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