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Association of squamous cell carcinoma of the oral cavity in allogeneic hematopoietic stem cell transplant recipients

Bone Marrow Transplantation volume 40, pages 907–909 (2007)Cite this article

Selected hematological malignancies can be cured by allogeneic hematopoietic stem cell transplant (allo-HSCT). Allo-HSCT conditioning regimens consist of various chemotherapeutic agents with or without radiation therapy, and may cause varying degrees of extra-medullary toxicity, specifically graft-versus-host disease (GvHD) and oral cavity mucositis. An important long-term complication following allo-HSCT has been secondary malignancies.1 We report a case series of allo-HSCT patients developing oral cancers after cure of their primary disease. We hypothesize that secondary oral-cavity squamous cell carcinomas can occur without oral chronic GvHD (cGvHD).

We retrospectively studied patients who initially underwent allo-SCT and developed secondary malignancies, focusing on patients who developed oral squamous cell carcinomas. Three cases are presented (Table 1).

Table 1 Patient demographics
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Figure 1

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Authors and Affiliations

  1. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA

    N M Reddy, T E Hahn, M Battiwalla, S L Smiley & P L McCarthy

  2. Department of Dentistry, Roswell Park Cancer Institute, Buffalo, NY, USA

    M A Sullivan

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  1. N M Reddy
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  2. M A Sullivan
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  3. T E Hahn
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  4. M Battiwalla
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  5. S L Smiley
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  6. P L McCarthy
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Correspondence to P L McCarthy.

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Reddy, N., Sullivan, M., Hahn, T. et al. Association of squamous cell carcinoma of the oral cavity in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant 40, 907–909 (2007). https://doi.org/10.1038/sj.bmt.1705833

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