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Urinary reactivation of polyoma BK virus but not adenovirus in paediatric and adolescent patients after haematopoietic stem cell transplantation

Bone Marrow Transplantation volume 37, pages 621–623 (2006)Cite this article

Haemorrhagic cystitis (HC) after haematopoietic stem cell transplantation (HSCT) is closely related to viral reactivation. Risk factors for HC include busulfan-based conditioning, graft-versus-host disease (GVHD), and infections by viruses, notably polyoma BK virus (BKV)1, 2 and adenovirus (AdV).3

In adult patients, we and others have consistently shown that BKV undergoes urinary reactivation.2, 4, 5 In paediatric patients, AdV reactivation has been reported to be a risk factor for HC.6 However, AdV-associated HC was reported mainly from Japan,7 but not observed in adult Chinese4 and Italian patients.8 As for BKV in paediatric HC patients, few data exist. In this study, we investigated prospectively a cohort of paediatric and adolescent patients for both BK and Ad viruria during HSCT.

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Authors and Affiliations

  1. Department of Medicine, Queen Mary Hospital, Hong Kong

    A Y-H Leung, A S-Y Wong & Y-L Kwong

  2. Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong

    G C-F Chan

  3. Department of Microbiology, Queen Mary Hospital, Hong Kong

    K-Y Yuen

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  1. A Y-H Leung
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  2. A S-Y Wong
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  3. G C-F Chan
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  4. K-Y Yuen
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  5. Y-L Kwong
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Leung, AH., Wong, AY., Chan, GF. et al. Urinary reactivation of polyoma BK virus but not adenovirus in paediatric and adolescent patients after haematopoietic stem cell transplantation. Bone Marrow Transplant 37, 621–623 (2006). https://doi.org/10.1038/sj.bmt.1705288

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