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Successful treatment of severe hemorrhagic cystitis with selective vesical artery embolization

Bone Marrow Transplantation volume 35, pages 529–530 (2005)Cite this article

Severe hemorrhagic cystitis (HC) can sometimes be life-threatening after stem cell transplantation (SCT). Its incidence ranges from 7 to 52%.1 Early HC is now seldom observed because of hyperhydration, urine alkalization and the routine use of mesna, a uroprotective agent that inactivates acrolein, the toxic metabolite of cyclophosphamide.2

Late-onset HC persists as a severe complication. Possible risk factors include grade II–IV acute graft-versus-host-disease, use of busulfan and/or total-body irradiation in the conditioning regimen, older age at transplant and certain viruses (polyoma BK and JC viruses, adenoviruses type 1 and 11, cytomegalovirus) which can reactivate in immune deficiency conditions.3

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Authors and Affiliations

  1. Institute of Hematology and Medical Oncology ‘L. and A. Seragnoli’, University of Bologna, St Orsola-Malpighi Hospital, Bologna, Italy

    F Palandri, F Bonifazi, S Falcioni, M Arpinati, M B Giannini, G Bandini & M Baccarani

  2. Institute of Radiology, University of Bologna, St Orsola Hospital, Bologna, Italy

    C Rossi & F Ansaloni

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  1. F Palandri
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  2. F Bonifazi
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  3. C Rossi
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  4. S Falcioni
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  5. M Arpinati
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  8. G Bandini
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  9. M Baccarani
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Palandri, F., Bonifazi, F., Rossi, C. et al. Successful treatment of severe hemorrhagic cystitis with selective vesical artery embolization. Bone Marrow Transplant 35, 529–530 (2005). https://doi.org/10.1038/sj.bmt.1704818

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