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CD34+ selected haematopoietic stem cell (HSC) not preceded by any immunosuppressive therapy as effective treatment for graft failure

Bone Marrow Transplantation volume 35, pages 521–522 (2005)Cite this article

Infusion of CD133+ selected HSC not preceded by any immunosuppressive treatment has recently been reported in this Journal by Lang et al,1 as an effective therapy for isolated thrombocytopenia post allogeneic bone marrow transplantation in a patient affected by Wiskott–Aldrich Syndrome. In this report the authors wonder whether other methods of HSC selection not based on CD133+ could have been equally effective.

We here report a case of graft failure occurring after a T-cell replete allogeneic HSC transplantation that was successfully treated using an infusion of CD34+ immunoselected HSC without any prior immunosuppression.

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References

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Authors and Affiliations

  1. Department of Hematology and Bone Marrow Transplantation, Ospedale Ferrarotto, Via S Citelli 6, 95100, Catania, Italy

    G Milone, A Tornello, S Leotta, M Poidomani, S Mercurio, B Farsaci, C Consoli, P Murgano & R Giustolisi

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  1. G Milone
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  2. A Tornello
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  3. S Leotta
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  4. M Poidomani
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  5. S Mercurio
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  6. B Farsaci
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  7. C Consoli
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  8. P Murgano
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  9. R Giustolisi
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Milone, G., Tornello, A., Leotta, S. et al. CD34+ selected haematopoietic stem cell (HSC) not preceded by any immunosuppressive therapy as effective treatment for graft failure. Bone Marrow Transplant 35, 521–522 (2005). https://doi.org/10.1038/sj.bmt.1704805

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