Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Late-onset Epstein–Barr virus (EBV)-negative extranodal B-precursor lymphoblastic lymphoma of donor origin after hematopoietic stem cell transplantation (HSCT)

Bone Marrow Transplantation volume 31, pages 1071–1072 (2003)Cite this article

B-cell post-transplant lymphoproliferative disorders (PTLDs) are an infrequent complication of allogenic stem cell transplantation, usually associated with Epstein–Barr virus (EBV)-infection. Mostly, the tumor cells are of donor origin and the lymphoproliferations resemble diffuse large B-cell lymphoma,1 but also T-cell lymphoma,2 Hodgkin's lymphoma,3 and even leukemias.1,4

Late-onset PTLDs occurring more than 1 year5 after transplantation do not share the same risk-factors as the more frequent early-onset PTLD, such as HLA mismatch, T-cell depletion, severe graft-versus-host disease (GVHD) and treatment with antithymocyte globulin.5

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Deeg HJ, Socie G . Malignancies after hematopoietic stem cell transplantation: many questions, some answers. Blood 1998; 91: 1833–1844.

    CAS  PubMed  Google Scholar 

  2. Zutter MM, Durnam DM, Hackman RC et al. Secondary T-cell lymphoproliferation after marrow transplantation. Am J Clin Pathol 1990; 94: 714–721.

    Article  CAS  PubMed  Google Scholar 

  3. Meignin V, Devergie A, Brice P et al. Hodgkin's disease of donor origin after allogeneic bone marrow transplantation for myelogeneous chronic leukemia. Transplantation 1998; 65: 595–597.

    Article  CAS  PubMed  Google Scholar 

  4. Lawler M, Locasciulli A, Longoni D et al. Leukaemic transformation of donor cells in a patient receiving a second allogeneic bone marrow transplant for severe aplastic anaemia. Bone Marrow Transplant 2002; 29: 453–456.

    Article  CAS  PubMed  Google Scholar 

  5. Curtis RE, Travis LB, Rowlings PA et al. Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. Blood 1999; 94: 2208–2216.

    CAS  PubMed  Google Scholar 

  6. Gomyo H, Murayama T, Kizaki T et al. Epstein-Barr virus-negative high grade B cell lymphoma of donor origin developing 19 months after unrelated allogeneic bone marrow transplantation. Bone Marrow Transplant 2000; 26: 577–579.

    Article  CAS  PubMed  Google Scholar 

  7. Nelson BP, Nalesnik MA, Bahler DW et al. Epstein–Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity? Am J Surg Pathol 2000; 24: 375–385.

    Article  CAS  PubMed  Google Scholar 

  8. Wilkens L, Bredt M, Flemming A et al. Detection of chromosomal aberrations in well-differentiated hepatocellular carcinoma by bright-field in situ hybridization. Mod Pathol 2002; 15: 470–477.

    Article  PubMed  Google Scholar 

  9. Kleeberger W, Rothamel T, Glockner S et al. High frequency of epithelial chimerism in liver transplants demonstrated by microdissection and STR-analysis. Hepatology 2002; 35: 110–116.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pathology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover, 30625, Germany

    M Bredt, W Kleeberger, E König & H Kreipe

  2. Institute of Pathology Germany,

    G Schönfeld

  3. Department for Hematology and Oncology, Städtisches Klinikum Magdeburg, Germany

    H Kröning & E Kettner

  4. Department for Hematology and Oncology, Universität Leipzig, Germany

    H K Al-Ali & D Niederwieser

Authors
  1. M Bredt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G Schönfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W Kleeberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E König
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H Kröning
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E Kettner
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H K Al-Ali
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. D Niederwieser
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. H Kreipe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bredt, M., Schönfeld, G., Kleeberger, W. et al. Late-onset Epstein–Barr virus (EBV)-negative extranodal B-precursor lymphoblastic lymphoma of donor origin after hematopoietic stem cell transplantation (HSCT). Bone Marrow Transplant 31, 1071–1072 (2003). https://doi.org/10.1038/sj.bmt.1704035

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704035

This article is cited by

Search

Advanced search

Quick links