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Regression of an unresectable pancreatic tumor following nonmyeloablative allogeneic peripheral-blood stem-cell transplantation

Bone Marrow Transplantation volume 31, pages 943–945 (2003)Cite this article

Summary:

A 59-year-old female with an unresectable, large pancreatic tumor (10.0 × 8.0 cm2 on CT scan) underwent nonmyeloablative allogeneic peripheral-blood stem-cell transplantation from her HLA-identical sibling. Pronounced tumor regression and relief from pain without acute graft-versus-host disease (GVHD) were observed following transplantation. The patient is surviving (more than 300 days) after transplantation, with extensive chronic GVHD, and has tumor regression with an 80% reduction in tumor size. The observed clinical course may suggest a graft-versus-tumor effect on the pancreatic tumor following allogeneic stem-cell transplantation.

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Authors and Affiliations

  1. Department of Chemotherapy, Tokyo Metropolitan Komagome Hospital, Hokomagome, Bunkyo-ku, Tokyo, Japan

    Y Omuro, T Sasaki & Y Maeda

  2. Department of Surgery, Tokyo Metropolitan Komagome Hospital, Hokomagome, Bunkyo-ku, Tokyo, Japan

    G Matsumoto & K Tsuruta

  3. Department of Hematology, Tokyo Metropolitan Komagome Hospital, Hokomagome, Bunkyo-ku, Tokyo, Japan

    Y Tanaka & H Sakamaki

  4. Department of Transfusion Service, Tokyo Metropolitan Komagome Hospital, Hokomagome, Bunkyo-ku, Tokyo, Japan

    K Hiruma

  5. Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    T Takahashi

Authors
  1. Y Omuro
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  2. G Matsumoto
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  3. T Sasaki
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  4. Y Tanaka
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  5. Y Maeda
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  6. H Sakamaki
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  7. K Hiruma
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  8. K Tsuruta
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  9. T Takahashi
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Omuro, Y., Matsumoto, G., Sasaki, T. et al. Regression of an unresectable pancreatic tumor following nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. Bone Marrow Transplant 31, 943–945 (2003). https://doi.org/10.1038/sj.bmt.1703932

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  • DOI: https://doi.org/10.1038/sj.bmt.1703932

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