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Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

Bone Marrow Transplantation volume 30, pages 195–198 (2002)Cite this article

Abstract

A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

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Acknowledgements

We thank Dr I Khouri, MD Anderson Cancer Center, USA, Dr J Hansen, Fred Hutchinson Cancer Research Center, USA, Dr R Gale, University of California Los Angeles, USA, and Dr J Martinez, University Hospital La Fe, Spain for good advice in planning the transplantation protocol, Miss Nakae for data collection, and the dialysis nurses and technicians for caring for this patient.

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Authors and Affiliations

  1. Department of Hematology, Toranomon Hospital, Tokyo, Japan

    T Hamaki, M Kami, H Yamakado, E Kusumi, J Ueyama, S Miyakoshi, S Morinaga & Y Mutou

  2. Department of Nephrology, Toranomon Hospital, Tokyo, Japan

    H Katori, T Yamato & S Hara

  3. Department of Pharmacology, Toranomon Hospital, Tokyo, Japan

    T Itoh, M Igarashi & M Hayashi

  4. Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan

    T Hamaki, M Kami, Y Kanda, S Mineishi & Y Takaue

  5. Department of Clinical Immunology and Hematology, Sapporo City General Hospital, Sapporo, Japan

    M Mukai

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  1. T Hamaki
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Hamaki, T., Katori, H., Kami, M. et al. Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis. Bone Marrow Transplant 30, 195–198 (2002). https://doi.org/10.1038/sj.bmt.1703584

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  • DOI: https://doi.org/10.1038/sj.bmt.1703584

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