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Eradication of a dysfunctional HLA-haploidentical T cell system by a second HLA-identical BMT

Bone Marrow Transplantation volume 28, pages 993–995 (2001)Cite this article

Abstract

A 12-year-old boy treated for SCID at 1 month of age by HLA-haploidentical BMT developed a lymphoproliferative disease of unknown etiology at the age of 9 years characterized by sustained, marked elevation of circulating CD8+ donor T cells and by diffuse infiltration of the liver by CD8+ T cells. Because of progressive liver disease, the patient underwent a second BMT from a younger HLA-matched sister. This treatment induced an effective graft-versus-graft reaction and led to complete replacement of the HLA-nonidentical, dysfunctional T cell system, resolution of the hepatopathy and full reconstitution of T and B cell functions. Bone Marrow Transplantation (2001) 28, 993–995.

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Authors and Affiliations

  1. Department of Paediatrics, University of Ulm, Ulm, Germany

    M Ege, AS Schulz, M Sigl-Kraetzig, K-M Debatin, W Friedrich & SM Mueller

  2. Department of Internal Medicine, University of Ulm, Ulm, Germany

    BJ Manfras

  3. Department of Genetics, University of Ulm, Ulm, Germany

    G Barbi

Authors
  1. M Ege
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  2. BJ Manfras
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  3. G Barbi
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  4. AS Schulz
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  5. M Sigl-Kraetzig
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  6. K-M Debatin
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  7. W Friedrich
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  8. SM Mueller
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Ege, M., Manfras, B., Barbi, G. et al. Eradication of a dysfunctional HLA-haploidentical T cell system by a second HLA-identical BMT. Bone Marrow Transplant 28, 993–995 (2001). https://doi.org/10.1038/sj.bmt.1703263

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  • DOI: https://doi.org/10.1038/sj.bmt.1703263

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