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Cord Blood Stem Cells

Bigger is better: maternal and neonatal predictors of hematopoietic potential of umbilical cord blood units

Bone Marrow Transplantation volume 27, pages 7–14 (2001)Cite this article

Abstract

Umbilical cord blood (CB) is a useful stem cell source for patients without matched family donors. CB banking is expensive, however, because only a small percentage of the cord units stored are used for transplantation. In this study, we determined whether maternal factors, such as race, age, and smoking status have an effect on laboratory parameters of hematopoietic potential, such as viability, cell counts, CD34+ cell counts, and CFU-GM. We studied the effect of neonatal characteristics such as birth order, birth weight, gestational age, and sex of the baby on the same laboratory parameters. Race and maternal age had no effect on these laboratory parameters. In multivariate analysis, babies of longer gestational age had higher cell counts, but lower CD34+ cell counts and CFU-GM. Bigger babies had higher cell counts, more CD34+ cells, and more CFU-GM. Women with fewer previous live births also produced cord units with higher cell counts, CFU-GM, and CD34+ cell counts. Specifically, each 500 g increase in birth weight contributed to a 28% increase in CD34+ cell counts, each week of gestation contributed to a 9% decrease in CD34+cell counts, and each previous birth contributed to a 17% decrease in CD34+ cell counts (all P < 0.05). These data may be used to select the optimal cord blood donors and allow CB banks efficient resource allocation. Bone Marrow Transplantation (2001) 27, 7–14.

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Acknowledgements

We acknowledge Carol Perch for her excellent technical assistance in preparation of the manuscript and Helen Valinski for her help in data organization.

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Authors and Affiliations

  1. University of Massachusetts Cancer Center, Worcester, MA, USA

    KK Ballen, AM Ceredona & PJ Quesenberry

  2. the American Red Cross Cord Blood Program, Dedham, MA, USA

    KK Ballen, M Wilson, J Wuu, C Hsieh, FM Stewart & MA Popovsky

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  1. KK Ballen
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Ballen, K., Wilson, M., Wuu, J. et al. Bigger is better: maternal and neonatal predictors of hematopoietic potential of umbilical cord blood units. Bone Marrow Transplant 27, 7–14 (2001). https://doi.org/10.1038/sj.bmt.1702729

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