Abstract
Tuberculosis is an uncommon infectious complication after stem cell transplantation. We report a patient who presented with a brain mass, 3 months after pulmonary tuberculosis had been diagnosed and while he was receiving triple antituberculous therapy. He had extensive chronic GVHD. The diagnosis was made after biopsy of the lesion. The cerebral mass was excised, antituberculous treatment was maintained and the patient made a complete neurologic recovery. Six months later, he died of gram-negative septic shock. Mycobacterial infections should be considered in allograft recipients with chronic GVHD and solid lesions in the brain. Bone Marrow Transplantation (2000) 25, 567–569.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Limon HB . Infections due to Mycobacteria. In: Dale DC (ed) Scientific American Medicine. University of Washington Medical Center: Seattle 1995 pp1–25
Snider D, La Montagne J . The neglected global tuberculosis problem: a report of the 1992 World Congress on Tuberculosis J Infect Dis 1994 169: 1189–1203
Roy V, Weisdorf D . Mycobacterial infections following bone marrow transplantation: a retrospective review of a 20 year experience Blood 1997 19: 460–470
Martino C, Martinez C, Domingo Albás A . Tuberculosis in bone marrow transplant recipients: report of two cases and review of the literature Bone Marrow Transplant 1996 18: 809–812
Openshaw H, Slatkin N . Neurological complications after hematopoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Cell Transplantation Blackwell Scientific Publications: Oxford 1998 pp659–673
Parkman R, Weinberg K . Immunological reconstitution following hematopoietic stem cell transplantation. In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Stem Cell Transplantation Blackwell Scientific Publications: Oxford 1998 pp 704–711
Shenoy S, Mohanakumar T . Immune reconstitution following allogeneic peripheral blood stem cell transplants Bone Marrow Transplant 1999 23: 335–346
Hoyle C, Goldman J . Life-threatening infections occurring more than 3 months after BMT Bone Marrow Transplant 1994 14: 247–252
Novari R, Sullivan K . Mycobacterial infections in marrow transplant recipients Transplantation 1983 36: 509–513
Kurzrock R, Zandler A . Mycobacterial pulmonary infections after allogeneic bone marrow transplantation Am J Med 1984 77: 35–40
Rouleau M, Lenick A . Long term persistence of transferred PPD-reactive T cells after allogeneic bone marrow transplantation Transplantation 1993 55: 72–76
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Campos, A., Vaz, C., Campilho, F. et al. Central nervous system (CNS) tuberculosis following allogeneic stem cell transplantation. Bone Marrow Transplant 25, 567–569 (2000). https://doi.org/10.1038/sj.bmt.1702163
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702163