Abstract
We report the cases of two severe aplastic anemia (SAA) patients who were successfully treated with syngeneic peripheral blood stem cell transplantation (PBSCT) using immunosuppression without high-dose chemotherapy or irradiation for conditioning. A 21-year-old woman with SAA of 6 years duration had been transfused heavily before transplantation and had developed refractory thrombocytopenia, chronic hepatitis and secondary hematochromatosis. Syngeneic PBSCT with immunosuppression using ATG, methylprednisolone, and cyclosporin-A was eventually performed without high-dose chemotherapy in September 1997. The second syngeneic PBSCT with the same immunosuppression was successfully performed in a 35-year-old male patient who had had SAA for 3 months in November 1998. Haemopoietic engraftment was rapid and sustained. There was no infection or mucositis during the syngeneic PBSCT. The patients are currently 9 to 22 months post-PBSCT without rejection. Our experience suggests that syngeneic PBSCT with brief immunosuppression is an effective alternative to pretransplant high-dose chemotherapy conditioning for SAA patients having syngeneic transplantation. Bone Marrow Transplantation (2000) 25, 337–339.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Camitta BM, Thomas ED, Nathan DG et al. Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality Blood 1976 48: 63–70
Gottdiener JS, Appelbaum FR, Ferrans VJ et al. Cardiotoxicity associated with high-dose cyclosphosphamide therapy Arch Intern Med 1981 141: 758–763
Sanders JE and the Seattle Marrow Transplantation Team . The impact of marrow transplant preparative regimens on subsequent growth and development Semin Hematol 1991 28: 244–249
Rosenfeld SJ, Kimball J, Vining D et al. Intensive immunosuppression with ATG and cyclosporine as treatment for severe aplastic anemia Blood 1995 85: 3058–3065
Hinterberger W, Rowlings PA, Fischer M et al. Results of transplant bone marrow for genetically identical twins into patients with aplastic anemia Ann Intern Med 1997 126: 116–122
Zoumbos NC, Gascon P, Djeu Y et al. Circulating activated suppressor T lymphocytes in aplastic anemia New Engl J Med 1985 312: 257–265
Hinterberger W, Adolf G, Bettelheim P et al. Lymphokine overproduction in severe aplastic anemia Blood 1988 74: 2713–2717
Marsh JC, Chang J, Testa NG et al. The hematopoietic defect in aplastic anemia assessed by long-term marrow culture Blood 1990 76: 1748–1757
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hwang, WL., Yang, Y., Chen, GR. et al. Syngeneic peripheral blood stem cell transplantation with brief immunosuppression for severe aplastic anemia. Bone Marrow Transplant 25, 337–339 (2000). https://doi.org/10.1038/sj.bmt.1702150
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702150