Abstract
A 2 year and 8 month old CMV-negative boy suffering from stage III neuroblastoma underwent ABMT in first very good partial remission. He acquired early CMV infection on day +5, followed by consecutive graft failure and severe sepsis, and the clincial course deteriorated. Between days +16 and +21, he received seven leukocyte concentrates (LC) collected from a healthy, but CMV-IgG-seropositive relative stimulated with G-CSF (filgastrim, 5 μg/kg/day). A median of 5.7 × 1010 neutrophils/m2/day (range, 1.2–8.3) were transfused, corresponding to a T cell number of roughly 4 × 108 CD3+ cells/kg/day. After infusion of the LCs, PCR analysis became negative for CMV and the patient received his rescue bone marrow. One year after ABMT, he is in complete remission and in good clinical condition. Our results suggest that the T cells infused together with the irradiated leukocytes played a major role in eradicating the CMV infection in this patient.
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Witt, V., Fritsch, G., Peters, C. et al. Resolution of early cytomegalovirus (CMV) infection after leukocyte transfusion therapy from a CMV seropositive donor. Bone Marrow Transplant 22, 289–292 (1998). https://doi.org/10.1038/sj.bmt.1701328
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DOI: https://doi.org/10.1038/sj.bmt.1701328
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