Abstract
HIGH-MOLECULAR polypeptides containing only one kind of amino-acid are prepared by polymerization of N-carboxylic-α-amino-acid anhydrides1 (α-amino-acid-NCA). The determination of the heat of combustion of these compounds and of the corresponding amino-acids offers for the first time the possibility of estimating quantitatively the energetics of formation of high-molecular peptide.
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References
Breitenbach, J. W., and Richter, F., “Die makromolekulare Chemie”, 4, 262 (1950). Wessely, F., Riedl, K., and Tuppy, H., Monats. Chem., 81, 861 (1950).
Fischer, E., and Wrede, F., Berliner Sitz., 687 (1904). Wrede, F., Z. physik. Chem., A, 75, 92 (1910).
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BREITENBACH, J., DERKOSCH, J. & WESSELY, F. Energetics of Peptide Formation. Nature 169, 922 (1952). https://doi.org/10.1038/169922a0
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DOI: https://doi.org/10.1038/169922a0
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