Abstract
PREVIOUSLY reported work1 from this laboratory indicated the feasibility of condensing 2-halo-3-thenoic acids to form symmetrically substituted 2,2′-bithienyls. This provided the experimental basis for the continuation of our studies in the field of mixed bi-aromatics, wherein it was shown2 that an unsymmetrically substituted α-phenylthiophene actually exists in two stereoisomeric forms due to restricted rotation. In view of this fact, the above method was applied to 3-halo-o-substituted thenoic acids in order to study the possible existence of optical activity in the corresponding β-phenylthiophenes. Accordingly, the synthesis of a symmetrically substituted 3,3′-bithienyl was undertaken.
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JEAN, G., OWEN, L. & NORD, F. Symmetrical Bi-Aromatics. Nature 169, 585 (1952). https://doi.org/10.1038/169585a0
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DOI: https://doi.org/10.1038/169585a0
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