Abstract
PREVIOUSLY we have observed that the respiratory quotient of animals, in which alloxan diabetes reaches a certain severity, is not appreciably affected by administration of thiamine + glucose1. Also, under the same experimental conditions, the administration of thiamine was not followed by a marked increase of liver cocarboxylase, whereas in normal animals or in those affected by less severe forms of the disease, such an increase does occur2. Therefore it was concluded that in alloxan diabetes a disturbance of the thiamine phosphorylation processes may occur.
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References
Siliprandi, N., Acta Vitaminologica, 4, 259 (1950).
Siliprandi, D., and Siliprandi, N., Nature, 168, 422 (1951).
Ochoa, S., and Peters, R. A., Biochem. J., 32, 1501 (1938).
Siliprandi, D., and Siliprandi, N., Acta Vitaminologica, 5, 3 (1951).
Bisceglie, V., Boll. Soc. It. Biol. Sper., 23, 224 (1947).
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SILIPRANDI, D., SILIPRANDI, N. Action of Insulin on Thiamine Phosphorylation. Nature 169, 329 (1952). https://doi.org/10.1038/169329a0
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DOI: https://doi.org/10.1038/169329a0
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