Abstract
AMONG removable groups employed for protecting the amino group of amino-acids and peptides, the phthalyl group has the advantage of giving stable and easily crystallizable derivatives1–5. Splitting of such N-phthalyl groups is usually accomplished by refluxing with alcoholic hydrazine hydroxide, followed by heating with dilute aqueous acid2–5.
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SCHUMANN, I., BOISSONNAS, R. Splitting of N-phthalyl Groups of Amino-acids with Phenylhydrazine. Nature 169, 154–155 (1952). https://doi.org/10.1038/169154a0
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DOI: https://doi.org/10.1038/169154a0
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