Abstract
WHILE a reasonable account can now be given of most stages of the mechanism of the urticarial type of skin response to injected antigens, the observed facts concerning the tuberculin or delayed type of reaction cannot yet be adequately explained. One of the main difficulties has been the failure to demonstrate circulating antibodies by the classical Prausnitz–Kuestner technique. However, Chase1 showed that sensitivity to tuberculin could be passively transferred by the intra-peritoneal or intravenous injection of white cell concentrates from sensitized animals. More recently, this finding has been confirmed by Lawrence2, who achieved passive transfer in the human by the intradermal injection of white cells from sensitized donors.
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References
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CRUICKSHANK, C. Sensitivity to Tuberculin. Nature 168, 206–207 (1951). https://doi.org/10.1038/168206b0
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DOI: https://doi.org/10.1038/168206b0
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