Abstract
Two members of the polymethylene α ω-bistrimethylammonium series1 ([N+(CH3)3.(CH2)n. N+(CH3)3] 2In) appear to possess activities which may be suitable for clinical use—the C 10 derivative (n = 10) to produce neuromuscular block, the C 6 derivative (n = 6) to produce ganglionic block. We wish to describe briefly the main characteristics of these compounds, in view of the great attention being paid to possible substitutes for d-tubocurarine chloride2,3 and to the use of tetraethylammonium iodide for ganglionic block4.
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PATON, W., ZAIMIS, E. Clinical Potentialities of Certain Bisquaternary Salts Causing Neuromuscular and Ganglionic Block. Nature 162, 810 (1948). https://doi.org/10.1038/162810a0
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DOI: https://doi.org/10.1038/162810a0
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