Abstract
IT is well known that N-methylnicotinamide is formed from nicotinamide by methylation in the human body, and Knox and Grossman1,2 have shown that N-methylnicotinamide is itself capable of being metabolized. These workers not only demonstrated that N-methylnicotinamide could be oxidized to N-methyl-2-pyridone-5-carboxylamide by an enzyme present in rabbit liver ; but they also succeeded in isolating the latter compound from human urine after the ingestion of doses of 0·6–0·9 gm. of nicotinamide per day.
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References
Knox, W. E., and Grossman, W. I., J. Biol. Chem., 166, 391 (1946).
Knox, W. E., and Grossman, W. I., J. Biol. Chem., 168, 363 (1947).
Maier-Bode, H., and Altpeter, J., "Das Pyridin und seine Derivate" (Wilhelm Knapp, Halle, 1934).
Meyer, H., Mh. Chem., 26, 1311 (1905).
von Pechmann, H., and Welsh, W., Ber. dtsch. chem. Ges., 17, 2384 (1884).
Räth, C., Frdl., 17, 2441 (1932).
Holman, W. I. M., and Wiegand, Chr., Biochem. J. (in the press).
Decker, H., Ber. dtsch. chem. Ges., 25, 443 (1892).
Decker, H., J. prakt. Chem., 47, 28 (1893).
Huff, J. W., J. Biol. Chem. 171, 639 (1947).
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WIEGAND, C., HOLMAN, W. Synthesis of Derivatives of N-Methyl-2-Pyridone from Nicotinic Acid and Nicotinamide. Nature 162, 659–660 (1948). https://doi.org/10.1038/162659a0
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DOI: https://doi.org/10.1038/162659a0
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