Abstract
THE recent clinical use of the nitrogen mustards for the treatment of Hodgkin‘s and other neoplastic diseases1 has focused attention on these compounds and more particularly on their biological action. The intensive study of these vesicants made during the War2, when they were regarded as potential chemical warfare agents, has been continued in the hope that more information will be gained about their action on animal tissues and about the basis of their therapeutic effect.
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References
Gilman, A., and Philips, F. S., Science, 103, 409 (1946). Rhoads, C. P., J. Amer. Med. Assoc., 131, 656 (1946). Goodman, L. S., Wintrobe, M. M., Dameshek, W., Goodman, M. J., Gilman, A., and McLennan, M. T., ibid., 132, 126 (1946). Jacobson, L. O., Spurr, C. L., Barren, E. S. G., Smith, T. R., Lushbaugh, C., and Dick, G. F., ibid., 132, 263 (1946). ApThomas, M. I. R., and Cullumbine, H., Lancet, 252, 899 (1947). Wilkinson, J. F., and Fletcher, F., ibid., 253, 540 (1947).
This was the subject of secret reports during the War, but much of it has since been published in scientific journals: cf. among others, Cameron, G. R., Courtice, F. C., and Jones, R. P., J. Path. Bact., 59, 425 (1947), and references (4), (5) and (6). Some of the war work was briefly reported at a symposium of the Biochemical Society (cf. report by Boyland, E., Nature, 161, 225 (1948)).
Boursnell, J. C., Francis, G. E., and Wormall, A., Biochem. J., 40, 774 (1946).
Hanby, W. E., and Rydon, H. N., J. Chem. Soc., 513 (1947).
Hanby, W. E., Hartley, G. S., Powell, E. O., and Rydon, H. N., J. Chem. Soc., 519 (1947). Cf. also Golumbic, C., Fruton, J. S., and Bergmann, M., J. Org. Chem., 11, 518 (1946), cited from Chem. Abstr., 41, 692 (1947).
Boyland, E., Brit. J. Pharmacol, 1, 247 (1946).
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WATKINS, W., WORMALL, A. Inactivation of Complement by Nitrogen Mustard. Nature 162, 535–536 (1948). https://doi.org/10.1038/162535a0
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DOI: https://doi.org/10.1038/162535a0
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