Abstract
BY oxidation with performic acid, the insulin molecule can be split into its separate polypeptide chains1. It has now been possible to prepare two fractions from the oxidized insulin : fraction A contains only glycine terminal residues and no arginine, histidine, lysine, phenylalanine or threonine ; fraction B contains 97 per cent phenylalanine terminal residues and all the amino-acids that are present in insulin. The yield of fraction A is more than 25 per cent of the original insulin, indicating that it represents more than one of the peptide chains of the insulin. The yield of fraction B is rather less.
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SANGER, F. Some Peptides from Insulin. Nature 162, 491–492 (1948). https://doi.org/10.1038/162491a0
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DOI: https://doi.org/10.1038/162491a0
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