Abstract
Oxidation of l(+)glutamic acid by brain tissue was first demonstrated in vitro by Quastel and Wheatley1. This work was developed by Krebs2 with reference to the function of glutamin and glutaminase. Weil-Malherbe3 suggested that l(+)glutamic acid fulfils a specific function in relation to carbohydrate metabolism in cerebral tissue. Latterly, Waelsch and his collaborators4 observed that the oral administration of dl-glutamic acid hydrochloride reduced the number of petit mal attacks in epileptics while it was without effect upon major seizures. Zimmerman et al.,5 confirming these observations, have claimed a favourable influence of the orally administered l(+)glutamic acid upon the intelligence of defective children.
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References
Quastel, J. H., and Wheatley, A. H. M., Biochem. J., 26, 725 (1932).
Krebs, H. A., Biochem. J., 29, 1951 (1935).
Weil-Malherbe, H., Biochem. J., 30, 665(1936).
Price, J. C., Waelsch, H., and Putman, T. J., J. Amer. Med. Assoc.,, 1153 (1943).
Zimmerman, F. T., Burgemeister, B. B., and Putman, T. J., Arch. Neur. and Psychiat., 56, 489 (1946).
Mayer-Gross, W., and Walker, J. W., Brit. J. Exp. Path., 26, 81 (1945).
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GROSS, W., WALKER, J. Effect of l(+)Glutamic Acid in Hypoglycæmia. Nature 160, 334 (1947). https://doi.org/10.1038/160334a0
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DOI: https://doi.org/10.1038/160334a0
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