Abstract
Objective:
Hepatitis C virus (HCV) infection exerts diverse effects on atherogenesis. We investigated whether malnutrition inflammation score (MIS) is associated with the presence of coronary artery disease (CAD) in anti-HCV-positive hemodialysis (HD) patients.
Subjects/Methods:
Twenty-two anti-HCV-positive HD patients with CAD and 61 anti-HCV-positive HD patients without CAD (as controls) were included. Data were obtained from hospital records, patients were evaluated for risk factors for CAD. The same physician performed MIS evaluation.
Results:
MIS of anti-HCV-positive HD patients with CAD were significantly higher than patients without CAD (8.8±4.0 vs 6.5±2.6, P=0.02). In patients with CAD, basal (P=0.002) and peak C-reactive protein (P=0.03) and serum ferritin (P=0.01) concentrations were higher, serum albumin concentrations (P=0.003) were lower than those patients without CAD. MIS was positively correlated with age (r=+0.359, P=0.001) and viral load (r=+0.629, P<0.0001). In univariate logistic regression analysis, advanced age (odds ratios (OR)=1.093, confidence interval (CI): 1.039–1.150, P=0.001), hypertension (OR=3.143, CI: 1.084–9.116, P=0.035), diabetes mellitus (OR=5.344, CI: 1.343–21.269, P=0.017), low triglyceride (OR=0.992, CI: 0.984–0.999, P=0.026) and high MIS (OR=1.259, CI: 1.066–1.488, P=0.007) were associated with the presence of CAD. Multivariate logistic regression analysis identified age (OR=1.090, CI: 1.007–1.179, P=0.033) and MIS as the factors associated with the presence of CAD (OR=1.232, CI: 1.004–1.511, P=0.04).
Conclusions:
MIS may be associated with CAD in anti-HCV-positive HD patients.
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Contributors: RE is the owner of the project collected data and wrote the manuscript; BA collected data and helped with the statistics; SS analyzed the results and approved the final version of the manuscript; ZA helped with the statistics; FNO analyzed the results; MH helped as a consultant.
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Elsurer, R., Afsar, B., Sezer, S. et al. Malnutrition inflammation score is associated with coronary artery disease in hepatitis C virus-infected hemodialysis patients. Eur J Clin Nutr 62, 1449–1454 (2008). https://doi.org/10.1038/sj.ejcn.1602867
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DOI: https://doi.org/10.1038/sj.ejcn.1602867
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