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Adult Home Parenteral Nutrition: a clinical evaluation after a 3-year experience in a Southern European centre

European Journal of Clinical Nutrition volume 60, pages 58–61 (2006)Cite this article

Abstract

Aim:

To evaluate the current use of Home Parenteral Nutrition (HPN) in a Southern European region.

Subjects and methods:

A total of 159 (86 m, 73 f) HPN patients, mean age 60.1±14.2 years, BMI 18.8±3.3 kg/m2, consecutively referred to the Artificial Nutrition outpatient Unit of the Federico II University Hospital in Naples (Italy), from January 2000 to December 2002 and treated for at least 4 weeks. Retrospective evaluation of baseline disease, indications and duration of HPN treatment, type of venous access, complications.

Results:

In all, 140 (88%) were cancer and 19 (12%) noncancer patients. Main indications were carcinosis in 68 for total, and hypophagia/dysphagia in 62 patients for partial/integrative (to oral-enteral nutrition) HPN; mean duration of HPN was 81.45±110.86 days of treatment and infection rate 2.89‰ in the whole population and 2.66‰ in the 36 patients treated for more than 3 months. No other major complications have been observed.

Conclusion:

HPN is confirmed to be a safe and effective treatment when prescribed and administered by a trained team.

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References

  • ASPEN Board of Directors and the Clinical Guidelines Task Force (2002). Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. JPEN 26 (1 Suppl), 1SA–138SA.

  • August DA, Thorn D, Fisher RL, Welchek CM (1991). Home parenteral nutrition for patients with inoperable malignant bowel obstruction. JPEN 15 (3), 323–327.

    Article  CAS  Google Scholar 

  • Balzola F, Gervasio S, Fadda M, De Francesco A, Orban A (2002). La Nutrizione Parenterale Domiciliare nel paziente neoplastico: dati del registro italiano. RINPE 2, 77.

    Google Scholar 

  • Bozzetti F (2003). Home parenteral nutrition in incurable cancer patients: a therapy, a basic human care or something between? Clin Nutr 22, 109–111.

    Article  CAS  Google Scholar 

  • Bozzetti F, Amadori D, Bruera E, Cozzaglio L, Coltri O, Filiberti A (1996). Guidelines on artificial nutrition versus hydration in terminal cancer patients. Eur Assoc Palliative Care Nutr 12 (3), 163–167.

    CAS  Google Scholar 

  • Buchman AL (2002). Must every cancer patients die with a central venous catheter? Clin Nutr 21, 269–271.

    Article  Google Scholar 

  • Contaldo F, Pasanisi F (2001). Appropriate use of (home) artificial nutrition: ethical implications. Clin Nutr 20 (2), 35–38.

    Google Scholar 

  • De Francesco A, Fadda M, Malfi G (1995). Home parenteral nutrition in Italy: data from the Italian National Register. Clin Nutr 14, 6–9.

    Article  Google Scholar 

  • Faisinger RL, Gramlich LM (1997). How often can we justify parenteral nutrition in terminally ill cancer patients? J Palliat Care 13 (1), 48–50.

    Google Scholar 

  • Howard L, Ament U, Fleming CR, Shike M, Steiger E (1995). Current use and clinical outcome of home parenteral and enteral nutrition therapies in the United States. Gastroenterology 109, 355–365.

    Article  CAS  Google Scholar 

  • Howard L, Hassan N (1998). Home Parenteral Nutrition, 25 years later. Gastroent. Clin North America 27 (2), 481–512.

    CAS  Google Scholar 

  • Howard L, Heaphey L, Fleming R, Lininger L, Steiger E (1991). Four years of North American Registry Home Parenteral Nutrition outcome data and their implications for patient management. JPEN 15 (4), 384–393.

    Article  CAS  Google Scholar 

  • Mac Fie J (1996). Ethical and legal considerations of recognizing nutrition support as a medical therapy. Bri J Surg 83 (11), 1567–1568.

    Article  CAS  Google Scholar 

  • Mughal M, Irving M (1986). Home Parenteral Nutrition in the United Kingdom and Ireland. Lancet 2 (8503), 383–387.

    Article  CAS  Google Scholar 

  • Planas M, Camilo ME (2002). Artificial nutrition: dilemmas in decision-making. Clin Nutr 21, 355–361.

    Article  Google Scholar 

  • Santarpia L, Pasanisi F, Alfonsi L, Violante G, Tiseo D, de Simone G et al. (2002). Prevention and treatment of implanted CVC-related sepsis: a report after 6 years of HPN. Clin Nutr 21, 207–211.

    Article  Google Scholar 

  • SINPE Executive Committee (2002a). Linee GuidaSINPE per la nutrizione artificiale ospedaliera 2002. RINPE S5, S5–S22.

  • SINPE Executive Committee (2002b). Ethical-deontological principles motivating artificial nutrition in good clinical practice. RINPE 2, 59–65.

  • Takagi Y, Okada A, Sato T, Fukushima T, Shirotani N, Osawa Y et al. (1995). Report on the first annual registry of home parenteral nutrition in Japan. Surg Today 25 (3), 193–201.

    Article  CAS  Google Scholar 

  • Van Gossum A, Bakker H, De Francesco A, Ladefoged K, Leon-Sanz M, Messing B et al. (1996). Home Parenteral Nutrition in adults: a multicentre survey in Europe in 1993. Clin Nutr 15, 53–59.

    Article  CAS  Google Scholar 

  • Van Gossum A, Bakker H, Bozzetti F, Staum M, Leon-Sanz M, Hébuterne X et al. (1999). Home parenteral nutrition in adults: an European multicentre survey in 1997. ESPEN-Home Artificial Nutrition Working Group. Clin Nutr 18, 135–140.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Internal Medicine and Clinical Nutrition, Federico II University, Naples, Italy

    G Violante, L Alfonsi, L Santarpia, M C Cillis, G Negro, C De Caprio, N Russo, F Contaldo & F Pasanisi

Authors
  1. G Violante
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  2. L Alfonsi
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  3. L Santarpia
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  4. M C Cillis
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  5. G Negro
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  6. C De Caprio
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  7. N Russo
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  8. F Contaldo
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  9. F Pasanisi
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Corresponding author

Correspondence to L Santarpia.

Additional information

Guarantors: F Pasanisi and F Contaldo.

Contributors: GV, LA, LS, carried out the literature research, designed the study, interpreted the data, conducted the statistical analysis and wrote the paper. MCC, GN, CDC, NR contributed to the design and interpretation of the study and the collection of the study data. FC, FP designed the study and contributed to the writing of the paper. FP supervised the statistical analysis.

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Violante, G., Alfonsi, L., Santarpia, L. et al. Adult Home Parenteral Nutrition: a clinical evaluation after a 3-year experience in a Southern European centre. Eur J Clin Nutr 60, 58–61 (2006). https://doi.org/10.1038/sj.ejcn.1602267

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