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Malnutrition in adults with cystic fibrosis

European Journal of Clinical Nutrition volume 59, pages 152–154 (2005)Cite this article

Abstract

Objective: To determine the prevalence and clinical features of malnutrition and its relationship with the CFTR genotype in a cystic fibrosis (CF) adult population.

Design: Cross-sectional study.

Setting: Department of Pulmonology, Cochin Hospital, Paris, France.

Subjects: 163 CF adults seen between 1997 and 1999.

Results: Mean age was 28.8 y. Mean body mass index (BMI) was 19.1 kg/m2. Malnutrition (BMI<18.5 kg/m2) was seen in 81 patients (49.7%). Its severity was associated with diagnosis of CF before the age of 18 y (P<0.01), FEV1 values below 30% (P<0.01), the yearly decline of FEV1 (P<0.01), pancreatic insufficiency (P<0.01) and gastro-oesophageal reflux (P<0.01). Malnutrition was observed in 58.7% of patients with a severe CFTR genotype but in 28.6% of patients with a mild genotype (P<0.001).

Conclusion: Malnutrition remains frequent in adults with CF except in patients presenting with a mild CFTR genotype (leading to a mild phenotype and to later diagnosis).

Sponsorship: None.

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Authors and Affiliations

  1. Service d'Hépato-Gastro-Entérologie, Hôpital Européen Georges Pompidou, Paris

    X Dray & P Marteau

  2. Service de Pneumologie, Hôpital Cochin, Paris

    R Kanaan, N Desmazes-Dufeu, D Dusser & D Hubert

  3. Service de Biochimie et Génétique Moléculaire, Hôpital Cochin, Paris

    T Bienvenu

Authors
  1. X Dray
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  2. R Kanaan
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  3. T Bienvenu
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  4. N Desmazes-Dufeu
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  5. D Dusser
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  6. P Marteau
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  7. D Hubert
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Corresponding author

Correspondence to D Hubert.

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Guarantor: D Hubert.

Contributors: XD collected most of the data, performed the statistical analysis and wrote the first version of the manuscript. RK participated in collecting additional data. TB performed the genetic molecular analysis. TB and DH classified the CFTR genotypes, DH, ND-D, DD enrolled and followed the patients as referent physicians for the respiratory manifestations of the disease. PM was the referent physician for the digestive complications of cystic fibrosis. All authors contributed to the editorial improvement of the manuscript.

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Dray, X., Kanaan, R., Bienvenu, T. et al. Malnutrition in adults with cystic fibrosis. Eur J Clin Nutr 59, 152–154 (2005). https://doi.org/10.1038/sj.ejcn.1602039

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602039

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