Abstract
Objective: To study the relationship between serum albumin and colorectal cancer occurrence.
Design: A case–control study nested within a cohort followed from 1968 to 1991.
Subjects and methods: The albumin concentration was determined from serum samples stored at −20°C at baseline in 177 incident colorectal cancer cases and 288 controls matched for sex, age and study region.
Results: An elevated risk was present of cancer of the left, distal colon at high serum albumin concentrations. No significant association was observed for the right, proximal colon or the rectum. The relative risks of cancer of the distal and proximal colon among individuals in the highest and lowest quartiles of serum albumin were 17.03 (95% confidence interval 1.48–195) and 0.77 (95% confidence interval 0.19–3.13), respectively.
Conclusions: The present study lends support to the hypothesis that some dietary factor associated with serum albumin may be a risk factor for distal colon cancer.
Sponsorship: This study was supported by a grant from the Swedish Cancer Foundation.
European Journal of Clinical Nutrition (2000) 54, 460–462
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Contributions
Guarantor: Dr P Knekt.
Contributors: P Knekt supervised the project, carried out the statistical analyses and prepared the draft; T Hakulinen provided the cancer incidence data; A Leino carried out the laboratory analyses; M Heliövaara participated in planning of the study design; A Reunanen participated in the conduction of the baseline data; R Stevens initiated the study and contributed to the interpretation of the data. All investigators contributed to the paper.
Rights and permissions
About this article
Cite this article
Knekt, P., Hakulinen, T., Leino, A. et al. Serum albumin and colorectal cancer risk. Eur J Clin Nutr 54, 460–462 (2000). https://doi.org/10.1038/sj.ejcn.1600997
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ejcn.1600997
Keywords
This article is cited by
-
Associations of Albumin and BMI with Colorectal Cancer Risk in the Southern Community Cohort Study: a Prospective Cohort Study
Journal of Racial and Ethnic Health Disparities (2023)
-
Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study
British Journal of Cancer (2017)
-
The Comparison of the Risk Factors and Clinical Manifestations of Proximal and Distal Colorectal Cancer
Diseases of the Colon & Rectum (2008)