Abstract
INCREASE in pressure inside the cranial cavity, whether local or general, first produces symptoms of cerebral irritation such as convulsions, contraction of the pupil, vomiting and rise of blood pressure, and is followed by coma, dilatation of the pupil, and other symptoms of paralysis of the nerve centres. The current explanation for this train of symptoms, which is seen in many pathological processes (for example, intracranial hæmorrhage, œdema, tumour, etc.), supposes that irritation is caused by congestion of the cerebral vessels and cyanosis, while further increase in pressure produces profound cerebral anaemia and coma.
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DIXON, K. A Metabolic Explanation for Irritation and Coma Produced by Rise in Intracranial Pressure. Nature 143, 380 (1939). https://doi.org/10.1038/143380a0
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DOI: https://doi.org/10.1038/143380a0
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