Abstract
IT has recently been shown1 that amino derivatives of acridine combine high antiseptic potency with low toxicity when the orientation of the amino group(s) is other than the 1- (that is, 9-) position. Unfortunately, the general synthetic methods available for preparing specific amino -acridines involve many stages and are usually wasteful of both time and material2, so that a general reaction for converting simple aromatic compounds to amino-acridines in a single operation would give valuable assistance in exploring further the chemotherapy of these compounds.
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References
Albert, Francis, Garrod and Linnell, Brit. J. Exper. Path., 19, 41 (1938); Albert, Dyer and Linnell, Quart. J. Pharm., 10, 649 (1937).
Cf. Albert and Linnell, J. Chem. Soc., 88, 1614 (1936); 22 (1938).
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ALBERT, A., LARGE, D. Preparation of 2: 8-Diamino-Acridine. Nature 142, 435 (1938). https://doi.org/10.1038/142435a0
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DOI: https://doi.org/10.1038/142435a0
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