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Resistance to viral infection of super p53 mice

Oncogene volume 24, pages 3059–3062 (2005)Cite this article

Abstract

Induction of expression of the tumor suppressor p53 after interferon treatment has been recently demonstrated (Takaoka et al., 2003), suggesting an antiviral activity of the protein. In addition, a direct correlation between p53 levels and tumor resistance has been addressed by generating mice with an extra copy of p53 (‘super p53’ mice) (Garcia-Cao et al., 2002). Here, we show that vesicular stomatitis virus replication in mouse embryo fibroblasts derived from ‘super p53’ mice is impaired as a result of apoptosis induction via p53 activation. These findings unequivocally demonstrate an antiviral activity of p53, a process that may contribute to inhibit the spread of the virus in vivo.

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Acknowledgements

We thank Victoria Jimenez for technical assistance on culture cells and viruses. We also thank Maribel Muñoz for great animal assistance. Work at the laboratory of M Serrano has been funded by the Spanish Ministry of Science and Technology (SAF2002-03402), and by the European Union (QLRT-2000-02084, QLRT-2000-00616 and INTACT). C Rivas laboratory work was supported by a grant from Ministerio de Ciencia y Tecnologia de España (BIO2002-02417). C Rivas is an investigator of the Ramon y Cajal Programme.

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Authors and Affiliations

  1. Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramon y Cajal sn, Madrid, 28040, Spain

    Cesar Mun̄oz-Fontela, Javier Arroyo & Carmen Rivas

  2. Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma de Madrid, Madrid, Spain

    Maria Angel Garcia & Mariano Esteban

  3. Spanish National Cancer Center (CNIO), Madrid, Spain

    Isabel Garcia-Cao, Manuel Collado & Manuel Serrano

Authors
  1. Cesar Mun̄oz-Fontela
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  2. Maria Angel Garcia
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Correspondence to Carmen Rivas.

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Mun̄oz-Fontela, C., Angel Garcia, M., Garcia-Cao, I. et al. Resistance to viral infection of super p53 mice. Oncogene 24, 3059–3062 (2005). https://doi.org/10.1038/sj.onc.1208477

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