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Structure and regulated expression of mammalian RUNX genes

Oncogene volume 23, pages 4211–4219 (2004)Cite this article

Abstract

The RUNX are key regulators of lineage-specific gene expression in major developmental pathways. The expression of RUNX genes is tightly regulated, leading to a highly specific spatio/temporal expression pattern and to distinct phenotypes of gene knockouts. This review highlights the extensive structural similarities between the three mammalian RUNX genes and delineates how regulation of their expression at the levels of transcription and translation are orchestrated into the unique RUNX expression pattern.

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Acknowledgements

We thank Ori Brenner, Joseph Lotem, Yael Bernstein, Varda Negreanu and Amir Pozner for helpful discussions and comments on the manuscript. The work was supported by grants from the Commission of the EU, the Israel Science Foundation, Minerva Foundation Germany and Shapell Family Biomedical Research Foundation at the Weizmann Institute.

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Levanon, D., Groner, Y. Structure and regulated expression of mammalian RUNX genes. Oncogene 23, 4211–4219 (2004). https://doi.org/10.1038/sj.onc.1207670

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