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Association of eNOS Glu298Asp gene polymorphism with circadian blood pressure rhythm

Journal of Human Hypertension volume 21, pages 501–503 (2007)Cite this article

Hypertensive patients with altered circadian blood pressure (BP) profile experience greater repercussion of hypertension on target organs and a higher risk of cardiovascular events, compared with those with physiological variations in BP. It has been demonstrated in animal models, that circadian variations in BP depend on several regulatory systems, in particular the nitric oxide-cGMP 1 pathway. eNOS298 Glu/Asp polymorphism is a functional variant and may alter the amount of NO generated or eNOS activity. 2 The objective of the present study was to find out whether eNOS298 gene polymorphism affects circadian BP regulation in 110 healthy subjects and 155 never-treated hypertensive patients recruited at Hypertension Units in Grenoble, Toulouse and Lille (France).

The inclusion criteria were: age between 20 and 65 years; no chronic disease; normal lipid levels (low-density lipoprotein cholesterol <1.90 g/l and triglycerides <2 g/l); and no concomitant treatments.

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Authors and Affiliations

  1. Service de Cardiologie et Hypertension artérielle, CHU Michallon, BP217X, Grenoble, France

    O Ormezzano, J-M Mallion & J-P Baguet

  2. Service de Médecine interne et hypertension artérielle, CHU Purpan, Toulouse, France

    J Amar & B Chamontin

  3. Service de Cardiologie, CHU de Lille, France

    C Mounier Vehier

  4. INSERM U525, Faculte de Medecine Pitie-Salpetriere, Paris, France

    F Cambien & O Poirier

  5. Département de Veille Sanitaire., CHU Michallon, BP217X, Grenoble, France,

    P François

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  1. O Ormezzano
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  2. J Amar
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  4. F Cambien
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  5. O Poirier
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  6. B Chamontin
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  8. J-M Mallion
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Correspondence to O Ormezzano.

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Ormezzano, O., Amar, J., Mounier Vehier, C. et al. Association of eNOS Glu298Asp gene polymorphism with circadian blood pressure rhythm. J Hum Hypertens 21, 501–503 (2007). https://doi.org/10.1038/sj.jhh.1002169

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