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Surrogate estimates of insulin sensitivity in subjects with hypertension

Journal of Human Hypertension volume 21, pages 246–252 (2007)Cite this article

Abstract

The purpose of the study is to compare surrogate estimates of insulin sensitivity with a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), in subjects with hypertension. Two hundred and twenty-eight hypertensive patients who received IST for SSPG were included for analysis. Estimates from fasting measurements alone, homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)), and indices from fasting and/or 2 h samples (ISI0,120 and ISITX) were calculated. In addition to Pearson and partial correlations, variance-component models were used to test the relationship between surrogate estimates of insulin sensitivity and SSPG. A large proportion of variance owing to covariates in the variance-component models indicated the goodness of model fit, irrespective of the independence among variables. SSPG was positively correlated with logarithmic transformation (Log) (HOMA-IR) and negatively correlated with QUICKI, Log (ISI0,120) and ISITX (all P<0.0001). Log (ISI0,120) seemed to have a better correlation with SSPG (r=−0.72) than other measures in partial correlation. The proportion of variance owing to all covariates of Log (ISI0,120) and ISITX were larger than those of Log (HOMA-IR) and QUICKI in the variance-component models. After adjustments for demographic and obesity covariates, the proportion of variance explained by Log (ISI0,120) were largest among the surrogate measures in the variance-component models. Our results showed that ISI0,120 and ISITX correlated better with SSPG than those used fasting measures alone (HOMA-IR and QUICKI). Log (ISI0,120) currently showing the strongest association with SSPG than other estimates is adaptable for use in large studies of hypertension.

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Acknowledgements

The study was supported by grants from the National Science Council ROC (NSC85-2331-B075-109Y, NSC86-2314-B075-099, NSC87-2312-B075-003Y), the National Health Research Institute ROC (DD01-86IX-MG-608S) and the National Heart, Lung and Blood Institute (U01HL54527-0151). Dr Chii-Min Hwu was also supported by the Taipei Veterans General Hospital (VGH-91-15A) and the Shih-Yuan Foundation for the Development of Internal Medicine (Grant No. 93008).

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Authors and Affiliations

  1. Department of Medicine, Section of General Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    C M Hwu

  2. Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan

    C M Hwu & L T Ho

  3. Division of Biostatistics and Bioinformatics, National Health Research Institutes, Miaoli, Taiwan

    C F Hsiao

  4. Department of Public Health Sciences and Epidemiology, University of Hawaii, Honolulu, Hawaii, USA

    J Grove & B Rodriguez

  5. Division of Endocrinology and Metabolism, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan

    Y J Hung

  6. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

    L M Chuang

  7. Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    Y T Chen

  8. Pacific Health Research Institute, Honolulu, Hawaii, USA

    J Grove, J D Curb & B Rodriguez

  9. Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Y D I Chen

  10. Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

    L T Ho

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Correspondence to C M Hwu.

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Hwu, C., Hsiao, C., Grove, J. et al. Surrogate estimates of insulin sensitivity in subjects with hypertension. J Hum Hypertens 21, 246–252 (2007). https://doi.org/10.1038/sj.jhh.1002137

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