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Haplotype association of the adrenergic β2 receptor gene with essential hypertension

Journal of Human Hypertension volume 20, pages 167–168 (2006)Cite this article

Essential Hypertension (EH) is a complex disorder resulting from the interplay of various genetic and environmental risk factors. Despite extensive efforts in the field, the underlying pathways leading to this complex phenotype remain elusive. However, during the past two decades, genetic studies including both the single point and haplotype associations investigating the components of important physiological blood pressure control systems have provided important insights into understanding EH. In this respect, the study of adrenergic receptors has been of great importance as their interaction with catecholamines plays an important role in influencing the control of vasomotion and regulating the metabolism of lipids, proteins and carbohydrates as well.1, 2 Several polymorphisms in the adrenergic β1 and β2 receptor genes have been found to be associated with EH, BMI and diabetes mellitus.3

In a previous issue of this journal, Wallerstedt et al.4 investigated the association of two polymorphisms in the adrenergic β2 receptor in patients with MI and found a particular haplotype to be associated with an increased risk of EH. As indicated earlier, their findings are not unique as the gene has previously been shown to be associated with EH.1, 3 However, the haplotype analyses as detailed in the study do not appear to have been conducted according to an appropriate method.

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Authors and Affiliations

  1. Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi, 74800, Pakistan

    D Saleheen, S Merwat & P Frossard

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  1. D Saleheen
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  2. S Merwat
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  3. P Frossard
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Correspondence to D Saleheen.

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Saleheen, D., Merwat, S. & Frossard, P. Haplotype association of the adrenergic β2 receptor gene with essential hypertension. J Hum Hypertens 20, 167–168 (2006). https://doi.org/10.1038/sj.jhh.1001949

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