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A haplotype in the human Sur2 gene is associated with essential hypertension

Journal of Human Hypertension volume 20, pages 87–90 (2006)Cite this article

Essential hypertension (EH) is considered to be multifactorial, and several factors have been identified. Several causal genes appear to contribute between 30 and 50% of the variation in blood pressure among individuals.1 These genetic determinants interact with environmental factors such as dietary salt to produce the final disease phenotype. Despite significant recent progress in genomic and statistical tools, the genetic dissection of human EH remains a major challenge.2

ATP-sensitive potassium (KATP) channels couple the intracellular energy state to membrane excitability, and regulate a wide array of biologic activities.3 KATP channels contain a pore-forming inwardly rectifying potassium channel and a sulfonylurea receptor regulatory subunit (Sur1 or Sur2).3 Surs are members of the ATP-binding cassette (ABC) transporter family of transmembrane proteins. The most extensive studies of the physiology and pharmacology of KATP channels have involved pancreatic β cells. Sulfonylurea agents such as glibenclamide inhibit KATP channels in pancreatic β cells by binding to Sur1, which results in closure of the channel and stimulation of insulin release.4 Recent studies indicate that KATP channels and Surs are involved in the physiology of the cardiovascular system.3 In cardiomyocytes, where KATP channels modulate protection from ischaemia, Sur1 and Sur2 are coexpressed.3 In smooth muscle and voluntary striated muscle, only Sur2 is expressed.3 In a 2003 study, mice with a targeted disruption of the Sur2 gene (Sur2−/−) had elevated resting blood pressure and experienced sudden death from coronary artery vasospasm with ST segment elevation.5

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Authors and Affiliations

  1. Division of Genomic Epidemiology and Clinical Trials, Advanced Medical Research Center, Tokyo, Japan

    N Sato & S Asai

  2. Division of Receptor Biology, Advanced Medical Research Center, Tokyo, Japan

    T Nakayama

  3. Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan

    M Soma

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  1. N Sato
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  2. T Nakayama
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  3. S Asai
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  4. M Soma
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Sato, N., Nakayama, T., Asai, S. et al. A haplotype in the human Sur2 gene is associated with essential hypertension. J Hum Hypertens 20, 87–90 (2006). https://doi.org/10.1038/sj.jhh.1001943

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