Abstract
OBJECTIVE:
Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations.
METHODS AND RESULTS:
CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1 y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5±4.9 to 32.3±5.3 kg/m2 1 y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (r=0.312, P<0.05), and between CRP and IL-6 (r=0.508, P<0.05), whereas no correlation was found between CRP and MMP-9.
CONCLUSIONS:
We conclude that weight loss is associated with a pronounced decrease in the nontraditional cardiovascular risk markers MMP-9 and CRP, which could indicate future beneficial effects of weight loss on the cardiovascular risk in weight loosing subjects.
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References
Manson JE, Willett WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, Hennekens CH, Speizer FE . Body weight and mortality among women. N Engl J Med 1995; 333: 677–685.
Stevens J, Cai J, Pamuk ER, Williamson DF, Thun MJ, Wood JL . The effect of age on the association between body-mass index and mortality. N Engl J Med 1998; 338: 1–7.
Libby P, Ridker PM, Maseri A . Inflammation and atherosclerosis. Circulation 2002; 105: 1135–1143.
Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB . Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999; 282: 2131–2135.
Ferroni P, Basili S, Martini F, Cardarello CM, Ceci F, Di Franco M, Bertazzoni G, Gazzaniga PP, Alessandri C . Serum metalloproteinase 9 levels in patients with coronary artery disease: a novel marker of inflammation. J Invest Med 2003; 51: 295–300.
Loftus IM, Naylor AR, Goodall S, Crowther M, Jones L, Bell PR, Thompson MM . Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption. Stroke 2000; 31: 40–47.
Torgerson JS, Sjostrom L . The Swedish Obese Subjects (SOS) study—rationale and results. Int J Obes Relat Metab Disord 2001; 25 (Suppl 1): S2–S4.
Ebenbichler CF, Laimer M, Kaser S, Ritsch A, Sandhofer A, Weiss H, Aigner F, Patsch JR . Relationship between cholesteryl ester transfer protein and atherogenic lipoprotein profile in morbidly obese women. Arterioscler Thromb Vasc Biol 2002; 22: 1465–1469.
Hanusch-Enserer U, Brabant G, Roden M . Ghrelin concentrations in morbidly obese patients after adjustable gastric banding. N Engl J Med 2003; 348: 2159–2160.
Laimer M, Ebenbichler CF, Kaser S, Sandhofer A, Weiss H, Nehoda H, Aigner F, Patsch JR . Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. Obes Res 2002; 10: 597–601.
Kopp HP, Kopp CW, Festa A, Krzyzanowska K, Kriwanek S, Minar E, Roka R, Schernthaner G . Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients. Arterioscler Thromb Vasc Biol 2003; 23: 1042–1047.
Laimer M, Ebenbichler CF, Kaser S, Sandhofer A, Weiss H, Nehoda H, Aigner F, Patsch JR . Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention. Int J Obes Relat Metab Disord 2002; 26: 659–662.
Hanusch-Enserer U, Cauza E, Spak M, Endler G, Dunky A, Tura A, Wagner O, Rosen HR, Pacini G, Prager R . Improvement of insulin resistance and early atherosclerosis in patients after gastric banding. Obes Res 2004; 12: 284–291.
Forsell P, Hallberg D, Hellers G . Gastric banding for morbid obesity: initial experience with a new adjustable band. Obes Surg 1993; 3: 369–374.
Nehoda H, Weiss H, Labeck B, Hourmont K, Lanthaler M, Oberwalder M, Aigner F . Results and complications after adjustable gastric banding in a series of 250 patients. Am J Surg 2001; 181: 12–15.
Hermans MP, Levy JC, Morris RJ, Turner RC . Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes. Diabetologia 1999; 42: 678–687.
Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H . A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 1996; 19: 1138–1141.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419.
Ridker PM, Haughie P . Prospective studies of C-reactive protein as a risk factor for cardiovascular disease. J Invest Med 1998; 46: 391–395.
Heilbronn LK, Noakes M, Clifton PM . Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women. Arterioscler Thromb Vasc Biol 2001; 21: 968–970.
Galis ZS, Sukhova GK, Lark MW, Libby P . Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 94: 2493–2503.
Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM . Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 1995; 91: 2125–2131.
Blankenberg S, Rupprecht HJ, Poirier O, Bickel C, Smieja M, Hafner G, Meyer J, Cambien F, Tiret L . Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation 2003; 107: 1579–1585.
Noji Y, Kajinami K, Kawashiri MA, Todo Y, Horita T, Nohara A, Higashikata T, Inazu A, Koizumi J, Takegoshi T, Mabuchi H . Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis. Clin Chem Lab Med 2001; 39: 380–384.
Moreau M, Brocheriou I, Petit L, Ninio E, Chapman MJ, Rouis M . Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages: relevance to stability of atherosclerotic plaque. Circulation 1999; 99: 420–426.
Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Scharnagl H, Hombach V, Koenig W . Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2003; 23: 283–288.
Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, Freed MI . Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 2002; 106: 679–684.
Acknowledgements
This study was supported by Grant No. 9442 of the Österreichische Nationalbank.
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Laimer, M., Kaser, S., Kranebitter, M. et al. Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women. Int J Obes 29, 498–501 (2005). https://doi.org/10.1038/sj.ijo.0802897
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DOI: https://doi.org/10.1038/sj.ijo.0802897
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