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Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p

International Journal of Obesity volume 29, pages 413–419 (2005)Cite this article

A Corrigendum to this article was published on 09 June 2005

Abstract

OBJECTIVE: To perform a meta-analysis of genome-wide linkage scans using body mass index (BMI) to identify genetic loci predisposing to obesity.

DATA: A total of 13 published genome scans on obesity have used BMI as their primary end point. Five of these 13 groups agreed to provide detailed results from their scans that were required for a meta-analysis. Collectively, these five studies included a total of 2814 individuals from 505 families.

METHODS: The results of the five studies were analysed using the GSMA (genome scans meta-analysis) method.

RESULTS: The analysis revealed significant evidence for linkage of the quantitative phenotype BMI to 8p (P<0.0005).

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Acknowledgements

This research was supported in part by NIH Grants DK54261 and P01 HL45522.

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Authors and Affiliations

  1. Mathematical Modelling and Genetic Epidemiology, Division of Genomic Medicine, University of Sheffield, UK

    L Johnson & M Dawn Teare

  2. Department of Preventative Medicine and Epidemiology, Loyola University Strich School of Medicine, Maywood, IL, USA

    A Luke

  3. Osteoporosis Research Centre, Creighton University, Omaha, NE, USA

    H-W Deng

  4. Department of Biomedical Sciences, Creighton University, Omaha, NE, USA

    H-W Deng

  5. Molecular and Statistical Genetics Lab, Hunan Normal University, ChangSha, China

    H-W Deng

  6. Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA

    B D Mitchell

  7. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA

    A G Comuzzie, S A Cole & J Blangero

  8. Department of Molecular Medicine, National public Health Institute University of Helsinki, Helsinki, Finland

    M Perola

  9. Department of Human Genetics, Gonda Neuroscience and Genetics Research Centre, University of California, Los Angeles, CA, USA

    M Perola

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  1. L Johnson
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Correspondence to M Dawn Teare.

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Johnson, L., Luke, A., Deng, HW. et al. Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p. Int J Obes 29, 413–419 (2005). https://doi.org/10.1038/sj.ijo.0802817

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