Abstract
BACKGROUND: Birth weight is positively associated with body mass index (BMI, kg/m2) in later life, but is inversely associated with cardiovascular risk. To understand this paradox, we examined the relationships between birth weight, adult BMI, and estimations of lean and fat tissue in young men.
METHODS: From 192 applicants for military service (ages 17–22 y, mean BMI 23.2 kg/m2) with known birth weights we measured the circumference and anterior skinfold thickness at midthigh to estimate thigh muscle+bone area and subcutaneous fat area. Linear regression models including birth weight as the independent variable were adjusted for race and adult height.
RESULTS: BMI was linearly associated with birth weight (standardized regression coefficient, [SRC]=+0.27; P=0.0004), as was the thigh muscle+bone area (SRC=+0.22; P=0.0029), but not the thigh subcutaneous fat area (SRC=+0.13; P=0.086). The BMI–birth weight association was reduced by 68% when the regression model was further adjusted for thigh muscle+bone area. Separate adjustment for thigh subcutaneous fat, however, reduced the BMI–birth weight association by only 30%. Waist circumference was also associated with birth weight (SRC=+0.24; P=0.0014), sagittal abdominal diameter was weakly associated (SRC=+0.17; P=0.028), but waist/thigh ratio and abdominal diameter index were not associated with birth weight.
INTERPRETATION: The larger BMI associated with higher birth weight may reflect increments in lean tissue more than increments in fat. Birth weight's influence on lean tissue is observed in the thigh and, among fit young men, perhaps at the waist. Increased muscularity in young men may partly explain the cardiovascular benefit in middle age ascribed to higher birth weight.
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References
Whincup PH, Cook DG, Adshead F, Taylor SJ, Walker M, Papacosta O, Alberti KG . Childhood size is more strongly related than size at birth to glucose and insulin levels in 10–11-year-old children Diabetologia 1997 40: 319–326.
Seidman DS, Laor A, Gale R, Stevenson DK, Danon YL . A longitudinal study of birth weight and being overweight in late adolescence Am J Dis Child 1991 145: 782–785.
Law CM, de Swiet M, Osmond C, Fayers PM, Barker DJ, Cruddas AM, Fall CH . Initiation of hypertension in utero and its amplification throughout life Br Med J 1993 306: 24–27.
Lithell HO, McKeigue PM, Berglund L, Mohsen R, Lithell UB, Leon DA . Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50–60 years Br Med J 1996 312: 406–410.
Leon DA, Koupilova I, Lithell HO, Berglund L, Mohsen R, Vagero D, Lithell UB, McKeigue PM . Failure to realise growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men Br Med J 1996 312: 401–406.
Frankel S, Elwood P, Sweetnam P, Yarnell J, Smith GD . Birthweight, body-mass index in middle age, and incident coronary heart disease Lancet 1996 348: 1478–1480.
Curhan GC, Chertow GM, Willett WC, Spiegelman D, Colditz GA, Manson JE, Speizer FE, Stampfer MJ . Birth weight and adult hypertension and obesity in women Circulation 1996 94: 1310–1315.
Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ . Birth weight and adult hypertension, diabetes mellitus, and obesity in US men Circulation 1996 94: 3246–3250.
Sorensen HT, Sabroe S, Rothman KJ, Gillman M, Fischer P, Sorensen TI . Relation between weight and length at birth and body mass index in young adulthood: cohort study Br Med J 1997 315: 1137.
Rasmussen F, Johansson M . The relation of weight, length and ponderal index at birth to body mass index and overweight among 18-year-old males in Sweden Eur J Epidemiol 1998 14: 373–380.
Dabelea D, Pettitt DJ, Hanson RL, Imperatore G, Bennett PH, Knowler WC . Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults Diabetes Care 1999 22: 944–950.
Shaper AG, Wannamethee SG, Walker M . Body weight: implications for the prevention of coronary heart disease, stroke, and diabetes mellitus in a cohort study of middle aged men Br Med J 1997 314: 1311–1317.
Stevens J, Cai J, Pamuk ER, Williamson DF, Thun MJ, Wood JL . The effect of age on the association between body-mass index and mortality N Engl J Med 1998 338: 1–7.
Barker DJP, Winter PD, Osmond C, Margetts B, Simmonds SJ . Weight in infancy and death from ischaemic heart disease Lancet 1989 2: 577–580.
Martyn CN, Barker DJ, Osmond C . Mothers’ pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK Lancet 1996 348: 1264–1268.
Martyn CN, Gale CR, Jespersen S, Sherriff SB . Impaired fetal growth and atherosclerosis of carotid and peripheral arteries Lancet 1998 352: 173–178.
Leon DA, Lithell HO, Vagero D, Koupilov I, Mohsen R, Berglund L, Lithell UB, McKeigue PM . Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15 000 Swedish men and women born 1915–29 Br Med J 1998 317: 241–245.
Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ . Catch-up growth in childhood and death from coronary heart disease: longitudinal study Br Med J 1999 318: 427–431.
Hediger ML, Overpeck MD, Kuczmarski RJ, McGlynn A, Maurer KR, Davis WW . Muscularity and fatness of infants and young children born small- or large-for-gestational-age Pediatrics 1998 102 E60. (http:\\www.pediatrics.org\cgi\content\full\102\5\e60).
Williamson DF, Kahn HS, Worthman CM, Burnette JC, Russell CM . Precision of recumbent anthropometry Am J Hum Biol 1993 5: 159–167.
World Health Organization Expert Committee on Physical Status . Physical Status: The Use and Interpretation of Anthropometry World Health Organization: Geneva 1995.
Mueller WH, Wear ML, Hanis CL, Emerson JB, Barton SA, Hewett-Emmett D, Schull WJ . Which measure of body fat distribution is best for epidemiologic research? Am J Epidemiol 1991 133: 858–869.
Seidell JC, Cigolini M, Charzewska J, Ellsinger B-M, Deslypere JP, Cruz A . Fat distribution in European men: a comparison of anthropometric measurements in relation to cardiovascular risk factors Int J Obes Relat Metab Disord 1992 16: 17–22.
Filipovsky J, Ducimetiere P, Darne B, Richard JL . Abdominal body mass distribution and elevated blood pressure are associated with increased risk of death from cardiovascular diseases and cancer in middle-aged men: the results of a 15- to 20-year follow-up in the Paris prospective study I Int J Obes Relat Metab Disord 1993 17: 197–203.
Kahn HS, Austin H, Williamson DF, Arensberg D . Simple anthropometric indices associated with ischemic heart disease J Clin Epidemiol 1996 49: 1017–1024.
National Center for Health Statistics, Najjar MF, Rowland M . Anthropometric reference data and prevalence of overweight, United States, 1976–80. Public Health Service: Hyattsville, MD 1987.
Phillips DIW . Relation of fetal growth to adult muscle mass and glucose tolerance Diabet Med 1995 12: 686–690.
Molarius A, Seidell JC . Selection of anthropometric indicators for classification of abdominal fatness—a critical review Int J Obes Relat Metab Disord 1998 22: 719–727.
National Heart Lung, and Blood Institute Obesity Education Initiative Expert Panel . Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults—the evidence report Obes Res 1998 6 (Suppl 2): 51S–209S.
Kvist H, Chowdhury B, Grangard U, Tylen U, Sjostrom L . Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations Am J Clin Nutr 1988 48: 1351–1361.
Barker DJ . Fetal origins of coronary heart disease Br Med J 1995 311: 171–174.
Hattersley AT, Tooke JE . The fetal insulin hypothesis: an alternative explanation of the association of low birth weight with diabetes and vascular disease Lancet 1999 353: 1789–1792.
Phillips DIW, Barker DJP, Hales CN, Hirst S, Osmond C . Thinness at birth and insulin resistance in adult life Diabetologia 1994 37: 150–154.
Clausen JO, Borch-Johnsen K, Pedersen O . Relation between birth weight and the insulin sensitivity index in a population sample of 331 young, healthy Caucasians Am J Epidemiol 1997 146: 23–31.
Leger J, Levy-Marchal C, Bloch J, Pinet A, Chevenne D, Porquet D, Collin D, Czernichow P . Reduced final height and indications for insulin resistance in 20 year olds born small for gestational age: regional cohort study Br Med J 1997 315: 341–347.
Hofman PL, Cutfield WS, Robinson EM, Bergman RN, Menon RK, Sperling MA, Gluckman PD . Insulin resistance in short children with intrauterine growth retardation J Clin Endocrinol Metab 1997 82: 402–406.
Martyn CN, Hales CN, Barker DJ, Jespersen S . Fetal growth and hyperinsulinaemia in adult life Diabet Med 1998 15: 688–694.
Law CM, Barker DJ, Osmond C, Fall CH, Simmonds SJ . Early growth and abdominal fatness in adult life J Epidemiol Community Health 1992 46: 184–186.
Seidell JC, Bjorntorp P, Sjostrom L, Sannerstedt R, Krotkiewski M, Kvist H . Regional distribution of muscle and fat mass in men-new insight into the risk of abdominal obesity using computed tomography Int J Obes 1989 13: 289–303.
Kohrt WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO . Insulin resistance in aging is related to abdominal obesity Diabetes 1993 42: 273–281.
Weidner MD, Gavigan KE, Tyndall GL, McCammon MR, Houmard JA . Which anthropometric indices of regional adiposity are related to the insulin resistance of aging? Int J Obes Relat Metab Disord 1995 19: 325–330.
Karter AJ, Mayer-Davis EJ, Selby JV, D . Agostino RB J, Haffner SM, Sholinsky P, Bergman R, Saad MF, Hamman RF. Insulin sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. The Insulin Resistance and Atherosclerosis Study Diabetes 1996 45: 1547–1555.
Seidell JC, Bjorntorp P, Sjostrom L, Kvist H, Sannerstedt R . Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels Metabolism 1990 39: 897–901.
Pouliot M-C, Despres J-P, Lemieux S, Moorjani S, Bouchard C, Tremblay A, Nadeau A, Lupien PJ . Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women Am J Cardiol 1994 73: 460–468.
Richelsen B, Pedersen SB . Associations between different anthropometric measurements of fatness and metabolic risk parameters in non-obese, healthy, middle-aged men Int J Obes Relat Metab Disord 1995 19: 169–174.
Colman E, Toth MJ, Katzel LI, Fonong T, Gardner AW, Poehlman ET . Body fatness and waist circumference are independent predictors of the age associated increase in fasting insulin levels in healthy men and women Int J Obes Relat Metab Disord 1995 19: 798–803.
Acknowledgements
The authors are grateful for the cooperation of the Atlanta Military Entrance Processing Station, US Department of Defense, and the Georgia Division of Vital Records and Health Statistics. Their participation does not imply institutional endorsement of our results or interpretations. Our manuscript benefited from thoughtful comments by Ted Thompson and Dr David Pettitt.
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Kahn, H., Narayan, K., Williamson, D. et al. Relation of birth weight to lean and fat thigh tissue in young men. Int J Obes 24, 667–672 (2000). https://doi.org/10.1038/sj.ijo.0801211
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DOI: https://doi.org/10.1038/sj.ijo.0801211
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