The direct C−H-difluoromethylation of pyridines represents a highly efficient economic way to access azines. However, the direct meta-difluoromethylation of pyridines remains elusive. Here, the authors demonstrate switchable meta- as well as para-C−H difluoromethylation of pyridines through radical processes by using oxazino pyridine intermediates.

The exploration of heterogeneous interfaces between metal oxides has received limited attention. Here the authors demonstrated the creation of MnO₂-Mn_xCo_3-xO₄ interfaces through controlled chemical reduction processes, effectively altering electron distribution and yielding a superior catalyst for ethane oxidation.

Stretchable phosphorescent materials have potential in applications such as wearable electronics, but achieving a suitable balance of emission and stretchability is challenging. Here, the authors report the use of microphase separation to show stretchability with emission lifetimes maintained.

Many natural products exist as families of structurally similar molecules, and therefore developing skeletal modifications of common intermediates offers flexible and powerful approaches for target synthesis. Here, the authors report a single-atom insertion into the framework of the benzenoid subfamily, providing access to the troponoid congeners.

Controlling multiple stereogenic centers in a single molecular scaffold represents a challenge for current switchable asymmetric catalysts. Here, the authors achieve asymmetric stereodivergency by means of a switchable supramolecular helical catalyst allowing all stereoisomers to be obtained with high and similar enantioselectivities.

The dynamics of planted forests in China over the past three decades have contributed ~1198tg of above-ground carbon storage.

Microbial reduction of nitrous oxide to dinitrogen is considered negligible under acidic conditions. However, Guang He et al. show that a co-culture of two bacterial species derived from acidic tropical forest soil can reduce nitrous oxide at pH 4.5.

Traders of financial options bet that firms’ stock prices will be affected by forecasts of seasonal climate produced by the U.S. National Oceanic and Atmospheric Administration. Firms are exposed throughout the economy, and traders spend more to hedge the news from more skillful forecasts

HIMU-type seamounts may be subducted elsewhere beneath the Mariana arc, but obvious HIMU-type components appear only in the initial stages of arc rifting due to the low melting degree and being consumed during the process of back-arc spreading.

A global digital atlas of persistent fronts in Large Marine Ecosystems reveals a rapid increase in subtropical and polar regions, and stable conditions or a slight decrease in tropical regions, a pattern not captured by climate projections and ocean models.

Skeletal ryanodine receptor controls calcium mobilization indispensable for muscle contraction. Here, authors combine cryo-EM and molecular dynamics to uncover the structural basis of the intricate regulation of this channel by calcium and magnesium.

Here the authors apply the Motif Activity on Pre-mRNA Processing (MAPP) tool to standard RNA sequencing data, thereby unravelling the co-regulation of splicing and polyadenylation by RNA-binding proteins and their dysregulation in cancer.

Dysregulation of basal progenitor cells induces esophageal tumorigenesis but the underlying mechanism is less explored. Here, the authors show that Jag1/2 deficiency promotes expansion of basal progenitor cells, leading to reduced squamous epithelial differentiation and enhanced formation of squamous cell carcinoma in the foregut.

MAPK-driven tumorigenesis is often related to epithelial dedifferentiation but the regulatory mechanism is less clear. Here, the authors show that MAPK activation upregulates USP15 to promote deubiquitylation and stability of TBX3, a transcription factor implicated in thyroid development and differentiation, driving tumorigenesis in a BRAFV600E thyroid tumor model.

The use of oncolytic viruses as a therapy for cancer is limited by mechanisms inhibiting viral replication in the tumor. Here, the authors show that a chemical derivative of itaconate, 4-octyl itaconate, increases oncolytic virus VSVΔ51 efficacy in various cancer models, through decreasing antiviral immunity.

Plasma proteins are a potential diagnostic tool to detect multiple diseases, including cancer. Here, the authors leverage multi-omics data to identify 1,463 proteins associated with 19 common cancers in UK Biobank participants. Reviewer Recognition:

Endurance athletes and sedentary type 2 diabetes patients swapped their lifestyle for 8 weeks. Athletes store and utilise saturated fat intensely for performant physical activity, and type 2 diabetes patients reversed their dysmetabolic lipid state after endurance training.

Previous studies of the skin have suggested a neutral-to-acidic pH gradient in the outermost layer. Here, the authors perform quantitative intravital pH imaging of the stratum corneum, the outermost epidermal layer, and demonstrate three distinct pH zones - rather than a gradient - with different biological functions.

Authors explore the utility of CD5L for treating experimental sepsis. CD5L deficiency exacerbates experimental sepsis. Conversely, administration of recombinant CD5L in WT mice augments neutrophil function, enhances bacterial control, and mitigates inflammation, leading to substantial improvements in disease outcomes.

The endoplasmic reticulum (ER) is a major site of lipid peroxidation during ferroptosis. Here authors show that the ER protein IRE1α determines ferroptosis induction via regulating glutathione synthesis independent of the unfolded protein response.

The dynamics of planted forests in China over the past three decades have contributed ~1198tg of above-ground carbon storage.

Traders of financial options bet that firms’ stock prices will be affected by forecasts of seasonal climate produced by the U.S. National Oceanic and Atmospheric Administration. Firms are exposed throughout the economy, and traders spend more to hedge the news from more skillful forecasts

Visualising the structure of museum objects is a crucial step in understanding the origin, state, and composition of cultural heritage artifacts. Here the authors present an approach for creating computed tomography reconstructions using only standard 2D radiography equipment already available in most larger museums.

Cities that experience compact development tend to witness more extreme rainfall over downtown than their rural surroundings, while the anomalies in extreme rainfall frequency diminish for cities with dispersed development patterns.

Human groups preserve cultural history in songs passed between generations. Here the authors show that musical histories are largely independent of the history preserved in genes and languages.