Physical cues from the extracellular environment influence the lineage commitment of stem cells. Now, experiments on human mesenchymal stem cells cultured on photodegradable hydrogels show that the cells' fate can also be determined by past physical environments.
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Eyckmans, J., Chen, C. Sticky mechanical memory. Nature Mater 13, 542–543 (2014). https://doi.org/10.1038/nmat3989
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DOI: https://doi.org/10.1038/nmat3989