Virus–host interactions

Virus–host interactions are the viral and host processes that occur during viral infection, which enable both partners to respond to each other.

Latest Research and Reviews

  • Research
    | Open Access

    The blooming alga Emiliania huxleyi and its viruses are a model for density-dependent virulent dynamics. However, Knowles et al. show that this host–virus system exhibits temperate dynamics at natural host densities, in a manner dependent on host physiology.

    • Ben Knowles
    • , Juan A. Bonachela
    • , Michael J. Behrenfeld
    • , Karen G. Bondoc
    • , B. B. Cael
    • , Craig A. Carlson
    • , Nick Cieslik
    • , Ben Diaz
    • , Heidi L. Fuchs
    • , Jason R. Graff
    • , Juris A. Grasis
    • , Kimberly H. Halsey
    • , Liti Haramaty
    • , Christopher T. Johns
    • , Frank Natale
    • , Jozef I. Nissimov
    • , Brittany Schieler
    • , Kimberlee Thamatrakoln
    • , T. Frede Thingstad
    • , Selina Våge
    • , Cliff Watkins
    • , Toby K. Westberry
    •  & Kay D. Bidle
  • Research
    | Open Access

    Bacteriophages and their hosts are involved in a constant evolutionary arms race that should lead to divergence between phage genes over time. Here, the authors recruit metagenomic reads to virus reference genomes and genome fragments in samples from cryoconite holes and show that phages with near-identical core genomes maintain diversity by possession of numerous flexible gene modules, where homologous genes present in the pan-genome interchange to create new phage variants.

    • Christopher M. Bellas
    • , Declan C. Schroeder
    • , Arwyn Edwards
    • , Gary Barker
    •  & Alexandre M. Anesio
  • Research |

    Chimeric antigen receptor T cells targeting HIV-infected cells prevent T cell loss and reduce virus in blood and tissues of HIV-infected humanized mice, highlighting a path toward a cell-based therapy for HIV infection.

    • Colby R. Maldini
    • , Daniel T. Claiborne
    • , Ken Okawa
    • , Tao Chen
    • , Derrick L. Dopkin
    • , Xiaochuan Shan
    • , Karen A. Power
    • , Radiana T. Trifonova
    • , Katharine Krupp
    • , Meredith Phelps
    • , Vladimir D. Vrbanac
    • , Serah Tanno
    • , Timothy Bateson
    • , George J. Leslie
    • , James A. Hoxie
    • , Christian L. Boutwell
    • , James L. Riley
    •  & Todd M. Allen
  • Research |

    The authors do a CRISPR-knockout selection to investigate host factors required for influenza replication. They identified IFIT2 as being repurposed by influenza to promote replication.

    • Vy Tran
    • , Mitchell P. Ledwith
    • , Thiprampai Thamamongood
    • , Christina A. Higgins
    • , Shashank Tripathi
    • , Max W. Chang
    • , Christopher Benner
    • , Adolfo García-Sastre
    • , Martin Schwemmle
    • , Adrianus C. M. Boon
    • , Michael S. Diamond
    •  & Andrew Mehle

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