Transplantation tolerance

Transplantation tolerance is a state in which the immune system of the recipient of a tissue or organ transplantation does not attack the transplanted tissue. Transplantation tolerance is induced by immunosuppression, and prevents rejection of the transplant.

Latest Research and Reviews

  • Reviews |

    Improved understanding of HLAs together with advances in HLA typing and antibody detection techniques have enabled transplantation of sensitized patients. Here, the authors discuss these advances as well as novel approaches to desensitization, immunomodulation and tolerance induction.

    • Robert A. Montgomery
    • , Vasishta S. Tatapudi
    • , Mary S. Leffell
    •  & Andrea A. Zachary
  • Reviews |

    The functions of the complement system are diverse and extend beyond its role in host defence; complement activation is now known to contribute to numerous immunological, inflammatory and age-related conditions, including kidney disorders. Here, John Lambris and colleagues discuss the key activating, regulatory, and effector mechanisms of the complement system. They highlight important crosstalk connections with other regulatory systems, and, with a focus on kidney disease and transplantation, describe the involvement of complement in clinical conditions as well as promising therapeutic approaches.

    • Daniel Ricklin
    • , Edimara S. Reis
    •  & John D. Lambris
  • Research
    | Open Access

    Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.

    • Muhammad M. Mohiuddin
    • , Avneesh K. Singh
    • , Philip C. Corcoran
    • , Marvin L. Thomas III
    • , Tannia Clark
    • , Billeta G. Lewis
    • , Robert F. Hoyt
    • , Michael Eckhaus
    • , Richard N. Pierson III
    • , Aaron J. Belli
    • , Eckhard Wolf
    • , Nikolai Klymiuk
    • , Carol Phelps
    • , Keith A. Reimann
    • , David Ayares
    •  & Keith A. Horvath
  • Reviews |

    The unique immunomodulatory properties of multipotent mesenchymal stromal cells (MSCs) make them a promising candidate for cell therapy in organ transplantation. Here, the authors review preclinical data that support the potential tolerance-inducing effects of MSCs in transplant models and the results of initial clinical studies in kidney transplantation.

    • Federica Casiraghi
    • , Norberto Perico
    • , Monica Cortinovis
    •  & Giuseppe Remuzzi

News and Comment

  • News and Views |

    Long-term immunosuppression in transplant recipients is associated with important adverse effects including increased risk of infection and malignancy. New data from the ONE Study suggests that use of cell-based medicinal products containing regulatory immune cells is a potentially useful therapeutic strategy to enable minimization of immunosuppression in these patients.

    • James M. Mathew
    •  & Joseph R. Leventhal
  • News and Views |

    Inactivation of the major histocompatibility complex and overexpression of the transmembrane protein CD47 renders induced pluripotent stem cells invisible to the immune system of the host.

    • Tom Shani
    •  & Jacob H. Hanna
  • Research Highlights |

    Nanoparticles designed to prevent training of myeloid cells infiltrating allografts can promote long-term transplant acceptance and immunological tolerance.

    • Lucy Bird
  • News and Views |

    Transplanting allogeneic pancreatic islets intraperitoneally by first encapsulating the islets within an alginate-based formulation results in reduced fibrosis and capsule clumping, and thus in improved islet survival.

    • Alexander E. Vlahos
    •  & Michael V. Sefton
  • News and Views |

    HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.

    • Georg A. B√∂hmig
    •  & Lionel Rostaing